Voltammetric quality control of biologically active additives: Determination of Zn, Cd, Pb, Cu, Fe, As, and Se

G. B. Slepchenko, É A. Zakharova, E. G. Cherempei, O. G. Filichkina, L. P. Zeman, N. P. Pikula, T. I. Shchukina

Результат исследований: Материалы для журналаСтатья

Выдержка

A new procedure for the voltammetric determination of toxic (As, Cd, Pb) and essential (Se, Cu, Zn, Fe) elements in various biologically active food additives (FAs) based on phytopreparations has been developed. Sample preparation includes the acid (HNO3 + H2O2) or UV destruction of interfering substances followed by the reduction of As(V) and Se(VI) to the corresponding electroactive As(III) and Se (IV) forms. The elements Zn, Cd, Pb, and Cu are simultaneously determined using a mercury film electrode; As and Fe are determined sequentially, and Se is analyzed separately using a gold/graphite electrode and an appropriate supporting electrolyte. The content of elements in various analyzed FAs varied in a broad range of concentrations (mg/kg): Zn, 0.3 - 10000; Cd, 0.001 - 0.5; Pb, 0.001 - 0.5; Cu, 0.1 - 200; As, 0.01 - 1.0; Fe, 20 - 2000; and Se, 0.1 - 50. Metrological attestation performed with a large number of samples (above 400) showed a repeatability of 9%, a reproducibility of 13%, and an accuracy of 30%. The proposed analytical procedure is included into the Federal Register of Methods issued by the State Standard Pharmacological Committee of the Russian Federation, which includes methods admitted for use in the field of State Metrological Control and Supervision, and is recommended for use in laboratories of FA producing plants, state sanitary-epidemiological supervision offices, etc.

Язык оригиналаАнглийский
Страницы (с-по)614-617
Число страниц4
ЖурналPharmaceutical Chemistry Journal
Том39
Номер выпуска11
DOI
СостояниеОпубликовано - 1 ноя 2005

Отпечаток

Quality Control
Food Additives
Electrodes
Graphite
Poisons
Mercury
Gold
Electrolytes
Pharmacology
Acids

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Цитировать

Voltammetric quality control of biologically active additives : Determination of Zn, Cd, Pb, Cu, Fe, As, and Se. / Slepchenko, G. B.; Zakharova, É A.; Cherempei, E. G.; Filichkina, O. G.; Zeman, L. P.; Pikula, N. P.; Shchukina, T. I.

В: Pharmaceutical Chemistry Journal, Том 39, № 11, 01.11.2005, стр. 614-617.

Результат исследований: Материалы для журналаСтатья

@article{36d68f2670af4a6dbf1a637139219166,
title = "Voltammetric quality control of biologically active additives: Determination of Zn, Cd, Pb, Cu, Fe, As, and Se",
abstract = "A new procedure for the voltammetric determination of toxic (As, Cd, Pb) and essential (Se, Cu, Zn, Fe) elements in various biologically active food additives (FAs) based on phytopreparations has been developed. Sample preparation includes the acid (HNO3 + H2O2) or UV destruction of interfering substances followed by the reduction of As(V) and Se(VI) to the corresponding electroactive As(III) and Se (IV) forms. The elements Zn, Cd, Pb, and Cu are simultaneously determined using a mercury film electrode; As and Fe are determined sequentially, and Se is analyzed separately using a gold/graphite electrode and an appropriate supporting electrolyte. The content of elements in various analyzed FAs varied in a broad range of concentrations (mg/kg): Zn, 0.3 - 10000; Cd, 0.001 - 0.5; Pb, 0.001 - 0.5; Cu, 0.1 - 200; As, 0.01 - 1.0; Fe, 20 - 2000; and Se, 0.1 - 50. Metrological attestation performed with a large number of samples (above 400) showed a repeatability of 9{\%}, a reproducibility of 13{\%}, and an accuracy of 30{\%}. The proposed analytical procedure is included into the Federal Register of Methods issued by the State Standard Pharmacological Committee of the Russian Federation, which includes methods admitted for use in the field of State Metrological Control and Supervision, and is recommended for use in laboratories of FA producing plants, state sanitary-epidemiological supervision offices, etc.",
author = "Slepchenko, {G. B.} and Zakharova, {{\'E} A.} and Cherempei, {E. G.} and Filichkina, {O. G.} and Zeman, {L. P.} and Pikula, {N. P.} and Shchukina, {T. I.}",
year = "2005",
month = "11",
day = "1",
doi = "10.1007/s11094-006-0030-x",
language = "English",
volume = "39",
pages = "614--617",
journal = "Pharmaceutical Chemistry Journal",
issn = "0091-150X",
publisher = "Springer New York",
number = "11",

}

TY - JOUR

T1 - Voltammetric quality control of biologically active additives

T2 - Determination of Zn, Cd, Pb, Cu, Fe, As, and Se

AU - Slepchenko, G. B.

AU - Zakharova, É A.

AU - Cherempei, E. G.

AU - Filichkina, O. G.

AU - Zeman, L. P.

AU - Pikula, N. P.

AU - Shchukina, T. I.

PY - 2005/11/1

Y1 - 2005/11/1

N2 - A new procedure for the voltammetric determination of toxic (As, Cd, Pb) and essential (Se, Cu, Zn, Fe) elements in various biologically active food additives (FAs) based on phytopreparations has been developed. Sample preparation includes the acid (HNO3 + H2O2) or UV destruction of interfering substances followed by the reduction of As(V) and Se(VI) to the corresponding electroactive As(III) and Se (IV) forms. The elements Zn, Cd, Pb, and Cu are simultaneously determined using a mercury film electrode; As and Fe are determined sequentially, and Se is analyzed separately using a gold/graphite electrode and an appropriate supporting electrolyte. The content of elements in various analyzed FAs varied in a broad range of concentrations (mg/kg): Zn, 0.3 - 10000; Cd, 0.001 - 0.5; Pb, 0.001 - 0.5; Cu, 0.1 - 200; As, 0.01 - 1.0; Fe, 20 - 2000; and Se, 0.1 - 50. Metrological attestation performed with a large number of samples (above 400) showed a repeatability of 9%, a reproducibility of 13%, and an accuracy of 30%. The proposed analytical procedure is included into the Federal Register of Methods issued by the State Standard Pharmacological Committee of the Russian Federation, which includes methods admitted for use in the field of State Metrological Control and Supervision, and is recommended for use in laboratories of FA producing plants, state sanitary-epidemiological supervision offices, etc.

AB - A new procedure for the voltammetric determination of toxic (As, Cd, Pb) and essential (Se, Cu, Zn, Fe) elements in various biologically active food additives (FAs) based on phytopreparations has been developed. Sample preparation includes the acid (HNO3 + H2O2) or UV destruction of interfering substances followed by the reduction of As(V) and Se(VI) to the corresponding electroactive As(III) and Se (IV) forms. The elements Zn, Cd, Pb, and Cu are simultaneously determined using a mercury film electrode; As and Fe are determined sequentially, and Se is analyzed separately using a gold/graphite electrode and an appropriate supporting electrolyte. The content of elements in various analyzed FAs varied in a broad range of concentrations (mg/kg): Zn, 0.3 - 10000; Cd, 0.001 - 0.5; Pb, 0.001 - 0.5; Cu, 0.1 - 200; As, 0.01 - 1.0; Fe, 20 - 2000; and Se, 0.1 - 50. Metrological attestation performed with a large number of samples (above 400) showed a repeatability of 9%, a reproducibility of 13%, and an accuracy of 30%. The proposed analytical procedure is included into the Federal Register of Methods issued by the State Standard Pharmacological Committee of the Russian Federation, which includes methods admitted for use in the field of State Metrological Control and Supervision, and is recommended for use in laboratories of FA producing plants, state sanitary-epidemiological supervision offices, etc.

UR - http://www.scopus.com/inward/record.url?scp=33645708303&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645708303&partnerID=8YFLogxK

U2 - 10.1007/s11094-006-0030-x

DO - 10.1007/s11094-006-0030-x

M3 - Article

AN - SCOPUS:33645708303

VL - 39

SP - 614

EP - 617

JO - Pharmaceutical Chemistry Journal

JF - Pharmaceutical Chemistry Journal

SN - 0091-150X

IS - 11

ER -