TY - JOUR
T1 - Voltammetric and amperometric determination of metoclopramide on boron-doped diamond film electrode
AU - Dejmkova, Hana
AU - Dag, Candan
AU - Barek, Jiri
AU - Zima, Jiri
PY - 2012/8/1
Y1 - 2012/8/1
N2 - New methods for the determination of metoclopramide, antiemetic and gastroprokinetic pharmaceutical, were developed, using differential pulse voltammetry (DPV) and flow injection analysis (FIA) with amperometric detection on a boron-doped diamond film electrode. Electrode pretreatment necessary to ensure the stable results was investigated and it was found, that while DPV requires frequent electrode cleaning, FIA with a sufficiently high flow rate can maintain a stable signal with no signs of electrode passivation. The calculated quantification limits of the DPV and FIA with amperometric detection were 0.13 μmol L -1 and 0.015 μmol L -1, respectively. The applicability of the new methods was verified by the determination of metoclopramide in a pharmaceutical preparation. FIA with amperometic detection proved to be sensitive, accurate and, due to the resistance of the electrode to the passivation, also simple to handle.
AB - New methods for the determination of metoclopramide, antiemetic and gastroprokinetic pharmaceutical, were developed, using differential pulse voltammetry (DPV) and flow injection analysis (FIA) with amperometric detection on a boron-doped diamond film electrode. Electrode pretreatment necessary to ensure the stable results was investigated and it was found, that while DPV requires frequent electrode cleaning, FIA with a sufficiently high flow rate can maintain a stable signal with no signs of electrode passivation. The calculated quantification limits of the DPV and FIA with amperometric detection were 0.13 μmol L -1 and 0.015 μmol L -1, respectively. The applicability of the new methods was verified by the determination of metoclopramide in a pharmaceutical preparation. FIA with amperometic detection proved to be sensitive, accurate and, due to the resistance of the electrode to the passivation, also simple to handle.
KW - Boron-doped diamond film electrode
KW - Differential pulse voltammetry
KW - Flow injection analysis
KW - Metoclopramide
KW - Passivation
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U2 - 10.2478/s11532-012-0056-8
DO - 10.2478/s11532-012-0056-8
M3 - Article
AN - SCOPUS:84867073929
VL - 10
SP - 1310
EP - 1317
JO - Central European Journal of Chemistry
JF - Central European Journal of Chemistry
SN - 1895-1066
IS - 4
ER -