Voltammetric and amperometric determination of metoclopramide on boron-doped diamond film electrode

Hana Dejmkova, Candan Dag, Jiri Barek, Jiri Zima

Результат исследований: Материалы для журналаСтатья

8 Цитирования (Scopus)


New methods for the determination of metoclopramide, antiemetic and gastroprokinetic pharmaceutical, were developed, using differential pulse voltammetry (DPV) and flow injection analysis (FIA) with amperometric detection on a boron-doped diamond film electrode. Electrode pretreatment necessary to ensure the stable results was investigated and it was found, that while DPV requires frequent electrode cleaning, FIA with a sufficiently high flow rate can maintain a stable signal with no signs of electrode passivation. The calculated quantification limits of the DPV and FIA with amperometric detection were 0.13 μmol L -1 and 0.015 μmol L -1, respectively. The applicability of the new methods was verified by the determination of metoclopramide in a pharmaceutical preparation. FIA with amperometic detection proved to be sensitive, accurate and, due to the resistance of the electrode to the passivation, also simple to handle.

Язык оригиналаАнглийский
Страницы (с-по)1310-1317
Число страниц8
ЖурналCentral European Journal of Chemistry
Номер выпуска4
СостояниеОпубликовано - 1 авг 2012
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

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