TY - JOUR
T1 - Vascular effects of ginseng compounds
AU - Maslov, L. N.
AU - Lishmanov, Yu B.
PY - 2008
Y1 - 2008
N2 - In the review it has been systematized data on the vascular effects of ginsenosides in vivo. It has been shown that ginsenosides increase a tolerance of isolated arteries to oxidative stress, hypoxia-reoxigenation, homocysteine and other pathogenic factors. It has been performed an analysis published works on the effects of triterpene saponines on the NO synthesis in the isolated endothelial cells, a proliferation of these cells, an apoptosis of endotheliocytes, a secretion of vascular endothelial growth factor by endothelial cells. It was exhibited data on the potency of ginsenosides to inhibit a proliferation of vascular smooth muscle cells. It has been discussed a molecular mechanisms of triterpene saponines action, their interaction with steroid hormone receptors, proteinkinases, NO-synthase, guanilyl cyclase, K Ca-channels, Ca2+-channels.
AB - In the review it has been systematized data on the vascular effects of ginsenosides in vivo. It has been shown that ginsenosides increase a tolerance of isolated arteries to oxidative stress, hypoxia-reoxigenation, homocysteine and other pathogenic factors. It has been performed an analysis published works on the effects of triterpene saponines on the NO synthesis in the isolated endothelial cells, a proliferation of these cells, an apoptosis of endotheliocytes, a secretion of vascular endothelial growth factor by endothelial cells. It was exhibited data on the potency of ginsenosides to inhibit a proliferation of vascular smooth muscle cells. It has been discussed a molecular mechanisms of triterpene saponines action, their interaction with steroid hormone receptors, proteinkinases, NO-synthase, guanilyl cyclase, K Ca-channels, Ca2+-channels.
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M3 - Article
C2 - 19093375
AN - SCOPUS:56649094162
VL - 71
SP - 58
EP - 68
JO - Eksperimental'naya i Klinicheskaya Farmakologiya
JF - Eksperimental'naya i Klinicheskaya Farmakologiya
SN - 0869-2092
IS - 5
ER -