Unmasking of aminoanthroquinone moiety through a ring opening in the presence of copper salts and a subsequent cross-coupling/recyclization cascade

S. F. Vasilevsky, L. M. Gornostaev, A. A. Stepanov, E. V. Arnold, I. V. Alabugin

Результат исследований: Материалы для журналаСтатья

10 Цитирования (Scopus)

Выдержка

In the presence of copper(I) salts, 3-bromo- or 3-iodoisoxazoles undergo isoxazole ring opening to give keto amines that can undergo further one-pot cascade cross-coupling/recyclization transformation into an extended flat polyaromatic ring system that can provide an interesting new platform for the design of DNA intercalators. If necessary, the three-step reaction cascade can be interrupted at a desired intermediate step through a judicious choice of reaction temperature and catalyst.

Язык оригиналаАнглийский
Страницы (с-по)1867-1870
Число страниц4
ЖурналTetrahedron Letters
Том48
Номер выпуска10
DOI
СостояниеОпубликовано - 5 мар 2007
Опубликовано для внешнего пользованияДа

Отпечаток

Intercalating Agents
Isoxazoles
Amines
Copper
Salts
Catalysts
Temperature
DNA

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Цитировать

Unmasking of aminoanthroquinone moiety through a ring opening in the presence of copper salts and a subsequent cross-coupling/recyclization cascade. / Vasilevsky, S. F.; Gornostaev, L. M.; Stepanov, A. A.; Arnold, E. V.; Alabugin, I. V.

В: Tetrahedron Letters, Том 48, № 10, 05.03.2007, стр. 1867-1870.

Результат исследований: Материалы для журналаСтатья

@article{d8c9dc52c37a475091b00a8aa62ba9d9,
title = "Unmasking of aminoanthroquinone moiety through a ring opening in the presence of copper salts and a subsequent cross-coupling/recyclization cascade",
abstract = "In the presence of copper(I) salts, 3-bromo- or 3-iodoisoxazoles undergo isoxazole ring opening to give keto amines that can undergo further one-pot cascade cross-coupling/recyclization transformation into an extended flat polyaromatic ring system that can provide an interesting new platform for the design of DNA intercalators. If necessary, the three-step reaction cascade can be interrupted at a desired intermediate step through a judicious choice of reaction temperature and catalyst.",
author = "Vasilevsky, {S. F.} and Gornostaev, {L. M.} and Stepanov, {A. A.} and Arnold, {E. V.} and Alabugin, {I. V.}",
year = "2007",
month = "3",
day = "5",
doi = "10.1016/j.tetlet.2006.12.129",
language = "English",
volume = "48",
pages = "1867--1870",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "10",

}

TY - JOUR

T1 - Unmasking of aminoanthroquinone moiety through a ring opening in the presence of copper salts and a subsequent cross-coupling/recyclization cascade

AU - Vasilevsky, S. F.

AU - Gornostaev, L. M.

AU - Stepanov, A. A.

AU - Arnold, E. V.

AU - Alabugin, I. V.

PY - 2007/3/5

Y1 - 2007/3/5

N2 - In the presence of copper(I) salts, 3-bromo- or 3-iodoisoxazoles undergo isoxazole ring opening to give keto amines that can undergo further one-pot cascade cross-coupling/recyclization transformation into an extended flat polyaromatic ring system that can provide an interesting new platform for the design of DNA intercalators. If necessary, the three-step reaction cascade can be interrupted at a desired intermediate step through a judicious choice of reaction temperature and catalyst.

AB - In the presence of copper(I) salts, 3-bromo- or 3-iodoisoxazoles undergo isoxazole ring opening to give keto amines that can undergo further one-pot cascade cross-coupling/recyclization transformation into an extended flat polyaromatic ring system that can provide an interesting new platform for the design of DNA intercalators. If necessary, the three-step reaction cascade can be interrupted at a desired intermediate step through a judicious choice of reaction temperature and catalyst.

UR - http://www.scopus.com/inward/record.url?scp=33846785242&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846785242&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2006.12.129

DO - 10.1016/j.tetlet.2006.12.129

M3 - Article

AN - SCOPUS:33846785242

VL - 48

SP - 1867

EP - 1870

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 10

ER -