Unmasking of aminoanthroquinone moiety through a ring opening in the presence of copper salts and a subsequent cross-coupling/recyclization cascade

S. F. Vasilevsky, L. M. Gornostaev, A. A. Stepanov, E. V. Arnold, I. V. Alabugin

Результат исследований: Материалы для журналаСтатья

10 Цитирования (Scopus)


In the presence of copper(I) salts, 3-bromo- or 3-iodoisoxazoles undergo isoxazole ring opening to give keto amines that can undergo further one-pot cascade cross-coupling/recyclization transformation into an extended flat polyaromatic ring system that can provide an interesting new platform for the design of DNA intercalators. If necessary, the three-step reaction cascade can be interrupted at a desired intermediate step through a judicious choice of reaction temperature and catalyst.

Язык оригиналаАнглийский
Страницы (с-по)1867-1870
Число страниц4
ЖурналTetrahedron Letters
Номер выпуска10
СостояниеОпубликовано - 5 мар 2007
Опубликовано для внешнего пользованияДа


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry