Ultrasound irradiation to visualize and trigger the release of doxorubicin from hybrid microparticles

S. Pavel Postnikov, Antonio Di Martino, S. Sergei Vlasov, V. Viktor Kurtukov, Vladimir Sedlarik

Результат исследований: Материалы для книги/типы отчетовМатериалы для конференции

Аннотация

In the presented work the simultaneous use of ultrasound in tracking and smart release was investigated. Hybrid microparticles based on an iron core coated by a polysaccharide were prepared and loaded with doxorubicin. The possibility to trigger and control the release of the payload was demonstrated by application of ultrasound cycles at different power and time length. Results clearly indicate a direct correlation between the intensity of the release with the two parameters. A preliminary test using Sus Domestic liver demonstrates the possibility to visualize the faith of the microparticles after injection at the target site by a linear array ultrasound transducer. The dual function of the ultrasound; to visualize the position of the microparticles and afterwards trigger the release by changing the frequency was demonstrated offering a great perspective for a future biomedical application.

Язык оригиналаАнглийский
Название основной публикацииNANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application
ИздательTANGER Ltd.
Страницы485-488
Число страниц4
ISBN (электронное издание)9788087294819
СостояниеОпубликовано - 1 янв 2018
Событие9th International Conference on Nanomaterials - Research and Application, NANOCON 2017 - Brno, Чешская Республика
Продолжительность: 18 окт 201720 окт 2017

Серия публикаций

НазваниеNANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application
Том2017-October

Конференция

Конференция9th International Conference on Nanomaterials - Research and Application, NANOCON 2017
СтранаЧешская Республика
ГородBrno
Период18.10.1720.10.17

ASJC Scopus subject areas

  • Biotechnology
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites

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  • Цитировать

    Postnikov, S. P., Di Martino, A., Vlasov, S. S., Kurtukov, V. V., & Sedlarik, V. (2018). Ultrasound irradiation to visualize and trigger the release of doxorubicin from hybrid microparticles. В NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application (стр. 485-488). (NANOCON 2017 - Conference Proceedings, 9th International Conference on Nanomaterials - Research and Application; Том 2017-October). TANGER Ltd..