UCNP-based photoluminescent nanomedicines for targeted imaging and theranostics of cancer

Evgenii L. Guryev, Anita S. Smyshlyaeva, Natalia Y. Shilyagina, Evgeniya A. Sokolova, Samah Shanwar, Alexey B. Kostyuk, Alexander V. Lyubeshkin, Alexey A. Schulga, Elena V. Konovalova, Quan Lin, Indrajit Roy, Irina V. Balalaeva, Sergey M. Deyev, Andrei V. Zvyagin

Результат исследований: Материалы для журнала › Статья › рецензирование

2 Цитирования (Scopus)

Аннотация

Theranostic approach is currently among the fastest growing trends in cancer treatment. It implies the creation of multifunctional agents for simultaneous precise diagnosis and targeted impact on tumor cells. A new type of theranostic complexes was created based on NaYF₄: Yb,Tm upconversion nanoparticles coated with polyethylene glycol and functionalized with the HER2-specific recombinant targeted toxin DARPin-LoPE. The obtained agents bind to HER2-overexpressing human breast adenocarcinoma cells and demonstrate selective cytotoxicity against this type of cancer cells. Using fluorescent human breast adenocarcinoma xenograft models, the possibility of intravital visualization of the UCNP-based complexes biodistribution and accumulation in tumor was demonstrated.

Язык оригинала	Английский
Номер статьи	4302
Журнал	Molecules
Том	25
Номер выпуска	18
DOI	https://doi.org/10.3390/molecules25184302
Состояние	Опубликовано - сен 2020
Опубликовано для внешнего пользования	Да

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

Доступ к документу

10.3390/molecules25184302

Другие файлы и ссылки

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Цитировать

Guryev, E. L., Smyshlyaeva, A. S., Shilyagina, N. Y., Sokolova, E. A., Shanwar, S., Kostyuk, A. B., Lyubeshkin, A. V., Schulga, A. A., Konovalova, E. V., Lin, Q., Roy, I., Balalaeva, I. V., Deyev, S. M., & Zvyagin, A. V. (2020). UCNP-based photoluminescent nanomedicines for targeted imaging and theranostics of cancer. Molecules, 25(18), [4302]. https://doi.org/10.3390/molecules25184302

UCNP-based photoluminescent nanomedicines for targeted imaging and theranostics of cancer. / Guryev, Evgenii L.; Smyshlyaeva, Anita S.; Shilyagina, Natalia Y.; Sokolova, Evgeniya A.; Shanwar, Samah; Kostyuk, Alexey B.; Lyubeshkin, Alexander V.; Schulga, Alexey A.; Konovalova, Elena V.; Lin, Quan; Roy, Indrajit; Balalaeva, Irina V.; Deyev, Sergey M.; Zvyagin, Andrei V.

В: Molecules, Том 25, № 18, 4302, 09.2020.

Результат исследований: Материалы для журнала › Статья › рецензирование

Guryev, Evgenii L. ; Smyshlyaeva, Anita S. ; Shilyagina, Natalia Y. ; Sokolova, Evgeniya A. ; Shanwar, Samah ; Kostyuk, Alexey B. ; Lyubeshkin, Alexander V. ; Schulga, Alexey A. ; Konovalova, Elena V. ; Lin, Quan ; Roy, Indrajit ; Balalaeva, Irina V. ; Deyev, Sergey M. ; Zvyagin, Andrei V. / UCNP-based photoluminescent nanomedicines for targeted imaging and theranostics of cancer. В: Molecules. 2020 ; Том 25, № 18.

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abstract = "Theranostic approach is currently among the fastest growing trends in cancer treatment. It implies the creation of multifunctional agents for simultaneous precise diagnosis and targeted impact on tumor cells. A new type of theranostic complexes was created based on NaYF4: Yb,Tm upconversion nanoparticles coated with polyethylene glycol and functionalized with the HER2-specific recombinant targeted toxin DARPin-LoPE. The obtained agents bind to HER2-overexpressing human breast adenocarcinoma cells and demonstrate selective cytotoxicity against this type of cancer cells. Using fluorescent human breast adenocarcinoma xenograft models, the possibility of intravital visualization of the UCNP-based complexes biodistribution and accumulation in tumor was demonstrated.",

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