Two types of conformational dynamics and thermo-sensor properties of praseodymium-DOTA by 1H/13C NMR

Sergey P. Babailov, Eugeny N. Zapolotsky, Alexander I. Kruppa, Pavel A. Stabnikov, Ivan A. Godovikov, Eduard V. Bocharov, Eduard S. Fomin

    Результат исследований: Материалы для журналаСтатья

    Аннотация

    In aqueous medium, [Pr(H2O)(DOTA)] (I) undergo a intramolecular interconversion between two conformers (here DOTA = 1, 4, 7, 10-tetraaza-1, 4, 7, 10-tetrakis (carboxymethyl)cyclododecan; n = 0, 1, 2). Two types of molecular dynamic processes were found {enantiomerization and interconversion of the square-anti-prismatic (SAP) to twisted-square-anti-prismatic conformers (TSAP)}. The free energies of activation of the SAP to TSAP interconversion (for I complex) are found to be 50 ± 3 and 54 ± 4 kJ mol−1 (according to 1H and 13C NMR respectively). And, the activation free energy of enantiomerization is ΔG 298 = 65 ± 2 kJ mol−1. It was evaluated that the activation energy of enantiomerization in [Gd(H2O) (DOTA)] (II) is 64 ± 2 kJ mol−1 (by analysis of the dependence of the free activation energy on the ionic radius of other lanthanide ions). The experimental paramagnetic LIS values of I are well fitted by linear dependence on 1/T. It was found that I may be used as NMR thermometric sensors for controlling the local temperature in aqueous medium.

    Язык оригиналаАнглийский
    Страницы (с-по)340-344
    Число страниц5
    ЖурналInorganica Chimica Acta
    Том486
    DOI
    СостояниеОпубликовано - 24 фев 2019

    ASJC Scopus subject areas

    • Physical and Theoretical Chemistry
    • Inorganic Chemistry
    • Materials Chemistry

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    Babailov, S. P., Zapolotsky, E. N., Kruppa, A. I., Stabnikov, P. A., Godovikov, I. A., Bocharov, E. V., & Fomin, E. S. (2019). Two types of conformational dynamics and thermo-sensor properties of praseodymium-DOTA by 1H/13C NMR. Inorganica Chimica Acta, 486, 340-344. https://doi.org/10.1016/j.ica.2018.10.044