Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide

Olga V. Bakina, Elena A. Glazkova, Natalia Valentinovna Svarovskaya, Aleksandr S. Lozhkomoev, Aleksandr M. Dygay, Aleksey A. Churin, Marat Izrailevich Lerner, Sergey G. Psakhie

Результат исследований: Материалы для книги/типы отчетовМатериалы для конференции

3 Цитирования (Scopus)

Выдержка

Aluminum oxides of various morphology and phase composition, including pseudoboehmite, have wide application in medicine. The novel hybrid material from polymer fibers and low-dimensional structures of pseudoboehmite fixed on them can be used as a wound dressing due to its highly absorbent and adsorbent properties. The in vivo investigation of acute and chronic toxicity of the novel hybrid material after a single dermal application in the acute experiment for 8 and 24 hours with outbred male and female rats reveals no irritation or other pathological changes. The chronic toxicity testing of the material after multiple dermal applications at two doses causes no death of animals and no pathological changes in their general condition, weight dynamics, and visceral morphology. The macro- and microscopy of internal organs shows no pathological changes as compared to control animals. The results obtained bear witness to the low potential risk of toxicity when using the hybrid material as a wound dressing.

Язык оригиналаАнглийский
Название основной публикацииAIP Conference Proceedings
ИздательAmerican Institute of Physics Inc.
Страницы31-34
Число страниц4
Том1623
ISBN (печатное издание)9780735412606
DOI
СостояниеОпубликовано - 2014
СобытиеInternational Conference on Physical Mesomechanics of Multilevel Systems 2014 - Tomsk, Российская Федерация
Продолжительность: 3 сен 20145 сен 2014

Другое

ДругоеInternational Conference on Physical Mesomechanics of Multilevel Systems 2014
СтранаРоссийская Федерация
ГородTomsk
Период3.9.145.9.14

Отпечаток

toxicity
aluminum oxides
animals
irritation
absorbents
bears
adsorbents
medicine
death
organs
rats
microscopy
dosage
fibers
causes
polymers

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Цитировать

Bakina, O. V., Glazkova, E. A., Svarovskaya, N. V., Lozhkomoev, A. S., Dygay, A. M., Churin, A. A., ... Psakhie, S. G. (2014). Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide. В AIP Conference Proceedings (Том 1623, стр. 31-34). American Institute of Physics Inc.. https://doi.org/10.1063/1.4901475

Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide. / Bakina, Olga V.; Glazkova, Elena A.; Svarovskaya, Natalia Valentinovna; Lozhkomoev, Aleksandr S.; Dygay, Aleksandr M.; Churin, Aleksey A.; Lerner, Marat Izrailevich; Psakhie, Sergey G.

AIP Conference Proceedings. Том 1623 American Institute of Physics Inc., 2014. стр. 31-34.

Результат исследований: Материалы для книги/типы отчетовМатериалы для конференции

Bakina, OV, Glazkova, EA, Svarovskaya, NV, Lozhkomoev, AS, Dygay, AM, Churin, AA, Lerner, MI & Psakhie, SG 2014, Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide. в AIP Conference Proceedings. том. 1623, American Institute of Physics Inc., стр. 31-34, Tomsk, Российская Федерация, 3.9.14. https://doi.org/10.1063/1.4901475
Bakina OV, Glazkova EA, Svarovskaya NV, Lozhkomoev AS, Dygay AM, Churin AA и соавт. Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide. В AIP Conference Proceedings. Том 1623. American Institute of Physics Inc. 2014. стр. 31-34 https://doi.org/10.1063/1.4901475
Bakina, Olga V. ; Glazkova, Elena A. ; Svarovskaya, Natalia Valentinovna ; Lozhkomoev, Aleksandr S. ; Dygay, Aleksandr M. ; Churin, Aleksey A. ; Lerner, Marat Izrailevich ; Psakhie, Sergey G. / Toxicity of the hybrid material based on low-dimensional structures of aluminum oxide. AIP Conference Proceedings. Том 1623 American Institute of Physics Inc., 2014. стр. 31-34
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AU - Svarovskaya, Natalia Valentinovna

AU - Lozhkomoev, Aleksandr S.

AU - Dygay, Aleksandr M.

AU - Churin, Aleksey A.

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AB - Aluminum oxides of various morphology and phase composition, including pseudoboehmite, have wide application in medicine. The novel hybrid material from polymer fibers and low-dimensional structures of pseudoboehmite fixed on them can be used as a wound dressing due to its highly absorbent and adsorbent properties. The in vivo investigation of acute and chronic toxicity of the novel hybrid material after a single dermal application in the acute experiment for 8 and 24 hours with outbred male and female rats reveals no irritation or other pathological changes. The chronic toxicity testing of the material after multiple dermal applications at two doses causes no death of animals and no pathological changes in their general condition, weight dynamics, and visceral morphology. The macro- and microscopy of internal organs shows no pathological changes as compared to control animals. The results obtained bear witness to the low potential risk of toxicity when using the hybrid material as a wound dressing.

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