The aim of the stidy was to investigate diagnostic value of myocardial scintigraphy with a new short living radionuclide 199TI for detection of myocardual ischemia and to elucidate the potential of this method for assessment of effects of calcium antagonists on myocardial perfusion in patients with ischemic heart disease. Myocardial scintigraphy was performed in 160 patients (105 patients with ischemic heart disease and 55 controls). In 51 patients scintigraphy was done before and after treatment with calcium antagonists. Myocardial scintigraphy with 199TI had high sentitivity (93%) and specificity (84%) for diagnosis of ischemic heart disease. Frequency of detection of perfusion defects directly depended on number of obstructed coronary arteries and on presence of postinfarction cardiosclerosis. Reduction of size of transient perfusion defects during treatment with calcium antagonists (isradipine, diltiazem, long acting verapamil) was observed in more that 50% of patients. Positive effect of these drugs on myocardial perfusion diminished with increase in number of obstructed vessels and in X-syndrome. In 20% of patients with ischemic heart disease therapy ith blockers of calcium channels was associated with expansion of zones of hypoperfusion without negative dynamics of clinical state. The latter fact made the use of myocardial perfusion scintigraphy especially important for the control of treatment with calcium anragonists.
|Состояние||Опубликовано - 1996|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine