The Role of NO Synthase in the Cardioprotective Effect of Substances of Humic Origin on the Model of Ischemia and Reperfusion of Isolated Rat Heart

T. V. Lasukova, M. V. Zykova, M. V. Belousov, A. S. Gorbunov, L. A. Logvinova, A. M. Dygai

Результат исследований: Материалы для журналаСтатья

Выдержка

The cardioprotective and inotropic effects of standardized active natural substance based on high-molecular-weight compounds of humic origin were studied on the model of global ischemia (40 min) and reperfusion of isolated perfused rat heart. Preventive administration of the test substance (0.1 mg/ml) before ischemia/reperfusion modeling reduced reperfusion contracture and necrotic death of cardiomyocytes and promoted recovery of myocardial contractility. Blockade of NO synthase with L-NAME (100 μM) abolished the above effects of the test substance. It was hypothesized that NO synthase plays an important role in the development of the cardioprotective and inotropic effects of the test natural substance.

Язык оригиналаАнглийский
Страницы (с-по)598-601
Число страниц4
ЖурналBulletin of Experimental Biology and Medicine
Том166
Номер выпуска5
DOI
СостояниеОпубликовано - 15 мар 2019

Отпечаток

Humic Substances
Nitric Oxide Synthase
Reperfusion
Rats
Ischemia
NG-Nitroarginine Methyl Ester
Molecular weight
Contracture
Cardiac Myocytes
Recovery
Molecular Weight

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Цитировать

The Role of NO Synthase in the Cardioprotective Effect of Substances of Humic Origin on the Model of Ischemia and Reperfusion of Isolated Rat Heart. / Lasukova, T. V.; Zykova, M. V.; Belousov, M. V.; Gorbunov, A. S.; Logvinova, L. A.; Dygai, A. M.

В: Bulletin of Experimental Biology and Medicine, Том 166, № 5, 15.03.2019, стр. 598-601.

Результат исследований: Материалы для журналаСтатья

@article{7f9624bfcc1f4ca78b21132953ac288a,
title = "The Role of NO Synthase in the Cardioprotective Effect of Substances of Humic Origin on the Model of Ischemia and Reperfusion of Isolated Rat Heart",
abstract = "The cardioprotective and inotropic effects of standardized active natural substance based on high-molecular-weight compounds of humic origin were studied on the model of global ischemia (40 min) and reperfusion of isolated perfused rat heart. Preventive administration of the test substance (0.1 mg/ml) before ischemia/reperfusion modeling reduced reperfusion contracture and necrotic death of cardiomyocytes and promoted recovery of myocardial contractility. Blockade of NO synthase with L-NAME (100 μM) abolished the above effects of the test substance. It was hypothesized that NO synthase plays an important role in the development of the cardioprotective and inotropic effects of the test natural substance.",
keywords = "active substance, heart, ischemia, NO synthase, reperfusion",
author = "Lasukova, {T. V.} and Zykova, {M. V.} and Belousov, {M. V.} and Gorbunov, {A. S.} and Logvinova, {L. A.} and Dygai, {A. M.}",
year = "2019",
month = "3",
day = "15",
doi = "10.1007/s10517-019-04399-y",
language = "English",
volume = "166",
pages = "598--601",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",
number = "5",

}

TY - JOUR

T1 - The Role of NO Synthase in the Cardioprotective Effect of Substances of Humic Origin on the Model of Ischemia and Reperfusion of Isolated Rat Heart

AU - Lasukova, T. V.

AU - Zykova, M. V.

AU - Belousov, M. V.

AU - Gorbunov, A. S.

AU - Logvinova, L. A.

AU - Dygai, A. M.

PY - 2019/3/15

Y1 - 2019/3/15

N2 - The cardioprotective and inotropic effects of standardized active natural substance based on high-molecular-weight compounds of humic origin were studied on the model of global ischemia (40 min) and reperfusion of isolated perfused rat heart. Preventive administration of the test substance (0.1 mg/ml) before ischemia/reperfusion modeling reduced reperfusion contracture and necrotic death of cardiomyocytes and promoted recovery of myocardial contractility. Blockade of NO synthase with L-NAME (100 μM) abolished the above effects of the test substance. It was hypothesized that NO synthase plays an important role in the development of the cardioprotective and inotropic effects of the test natural substance.

AB - The cardioprotective and inotropic effects of standardized active natural substance based on high-molecular-weight compounds of humic origin were studied on the model of global ischemia (40 min) and reperfusion of isolated perfused rat heart. Preventive administration of the test substance (0.1 mg/ml) before ischemia/reperfusion modeling reduced reperfusion contracture and necrotic death of cardiomyocytes and promoted recovery of myocardial contractility. Blockade of NO synthase with L-NAME (100 μM) abolished the above effects of the test substance. It was hypothesized that NO synthase plays an important role in the development of the cardioprotective and inotropic effects of the test natural substance.

KW - active substance

KW - heart

KW - ischemia

KW - NO synthase

KW - reperfusion

UR - http://www.scopus.com/inward/record.url?scp=85063715754&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063715754&partnerID=8YFLogxK

U2 - 10.1007/s10517-019-04399-y

DO - 10.1007/s10517-019-04399-y

M3 - Article

C2 - 30903506

AN - SCOPUS:85063715754

VL - 166

SP - 598

EP - 601

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 5

ER -