Аннотация
When injected intraperitoneally in a dose of 8 mg/kg, U-62066, the selective agonist of κ-opioid receptors, exhibits antiarrhythmic properties in epinephrine-induced arrhythmias in rats. In cerebroventricular injection, the κ-agonists U-50,488 and [D-ala2]-dynorphin A(1-13) manifest proarrhythmic properties. Preliminary administration of the κ-antagonist nor-binaltorphimine completely removes the proarrhythmic and antiarrhythmic effect of κ-agonists. The antiarrhythmic effect of U-62006 is believed to be associated with activation of peripheral κ-receptors.
| Язык оригинала | Английский |
|---|---|
| Страницы (с-по) | 22 |
| Число страниц | 1 |
| Журнал | Eksperimental'naya i Klinicheskaya Farmakologiya |
| Том | 59 |
| Номер выпуска | 6 |
| Состояние | Опубликовано - 1996 |
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
Fingerprint Подробные сведения о темах исследования «The participation of central and peripheral κ-opioid receptors in the mechanism of the antiarrhythmic effect of benzeneacetamide derivatives». Вместе они формируют уникальный семантический отпечаток (fingerprint).
Цитировать
Maslov, L. N., Lishmanov, Y. B., Krylatov, A. V., & Ugdyzhekova, D. S. (1996). The participation of central and peripheral κ-opioid receptors in the mechanism of the antiarrhythmic effect of benzeneacetamide derivatives. Eksperimental'naya i Klinicheskaya Farmakologiya, 59(6), 22.