The influence of implantation of plasma-modified polylactic acid films on the structure of the cornea

Ekaterina O. Filippova, Anna D. Zhuravleva, Evgeniya A. Gorbunova, Nina M. Ivanova

Результат исследований: Материалы для книги/типы отчетовМатериалы для конференции

Аннотация

The purpose of this research is the study the influence of the plasma-modified PLA films implantation on the morphology of the cornea in vivo experiment. Studies were performed on 12 pubescent female Sylvilagus bachmani rabbits. Plasma-modified PLA films were implanted into the anterior chamber of one animal eye. The feedstock for the films was obtained by dissolving PLA in the chloroform. Modification of the films was carried out using the low-temperature plasma. Such methods as visual check, photographic registration, non-contact ocular tonometry and optical coherent tomography of cornea were also used in the course of the experiment. Sampling was performed on day 21 after the start of the experiment for morphology studying. Results showed that the implantation of the plasma-modified PLA films contributes to the development of the mild inflammatory response (mild leukocyte infiltration, newly formed blood vessels, increased twisted stroke of collagen fibers, and presence of strongly acid sulfated GAGs) as a result of the surgery. The study showed the possibility of PLA films using as a corneal implant.

Язык оригиналаАнглийский
Название основной публикацииProceedings of the International Conference on Physical Mesomechanics. Materials with Multilevel Hierarchical Structure and Intelligent Manufacturing Technology
РедакторыVictor E. Panin, Vasily M. Fomin
ИздательAmerican Institute of Physics Inc.
ISBN (электронное издание)9780735440463
DOI
СостояниеОпубликовано - 14 дек 2020
СобытиеInternational Conference on Physical Mesomechanics. Materials with Multilevel Hierarchical Structure and Intelligent Manufacturing Technology 2020 - Tomsk, Российская Федерация
Продолжительность: 5 окт 20209 окт 2020

Серия публикаций

НазваниеAIP Conference Proceedings
Том2310
ISSN (печатное издание)0094-243X
ISSN (электронное издание)1551-7616

Конференция

КонференцияInternational Conference on Physical Mesomechanics. Materials with Multilevel Hierarchical Structure and Intelligent Manufacturing Technology 2020
СтранаРоссийская Федерация
ГородTomsk
Период5.10.209.10.20

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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