The foundations of the development of technologies of the synthesis of radiopharmaceuticals

M. Larkina, E. Podrezova, O. Bragina, E. Stasyuk, M. Yusubov, V. Chernov, R. Zelchan, V. Skuridin, M. Belousov, S. Deyev

Результат исследований: Материалы для книги/типы отчетовМатериалы для конференции

Аннотация

The selection of precursors (for example chelating agents) and development of a technique of chemical modification of the target molecules retaining its ability to bind to specific receptors are very important in the synthesis of radiopharmaceuticals. As some important precursors for target radiopharmaceuticals omega-iodo-aliphatic carboxylic acids and their esters can be used. We have developed an environmentally safe process for producing omega-iodo-aliphatic carboxylic acids and their esters of the available, inexpensive and low toxic aliphatic cyclic ketones. We proposed a new method for the synthesis of the chelating agents omega-thia- or (bis(2-hydroxyethyl)amino)- aliphatic carboxylic acids (chelate 1 and chelate 2), which was caused by the existing disadvantages in the existing methods. Thus, based on our method the precursors (chelates) with yield of over 70-90% on the final stage were synthesized, and then the high effectiveness in producing target radiopharmaceuticals using different biomolecules was showed. 99mTc-chelates complexes were prepared with radiochemical purity >91% and found to be stable at room temperature for six hours.

Язык оригиналаАнглийский
Название основной публикацииPhysics of Cancer
Подзаголовок основной публикацииInterdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017
РедакторыElazar Y. Gutmanas, Oleg B. Naimark, Yurii P. Sharkeev
ИздательAmerican Institute of Physics Inc.
Том1882
ISBN (электронное издание)9780735415621
DOI
СостояниеОпубликовано - 28 сен 2017
СобытиеInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 - Tomsk, Российская Федерация
Продолжительность: 23 мая 201726 мая 2017

Конференция

КонференцияInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017
СтранаРоссийская Федерация
ГородTomsk
Период23.5.1726.5.17

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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  • Цитировать

    Larkina, M., Podrezova, E., Bragina, O., Stasyuk, E., Yusubov, M., Chernov, V., Zelchan, R., Skuridin, V., Belousov, M., & Deyev, S. (2017). The foundations of the development of technologies of the synthesis of radiopharmaceuticals. В E. Y. Gutmanas, O. B. Naimark, & Y. P. Sharkeev (Ред.), Physics of Cancer: Interdisciplinary Problems and Clinical Applications - Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 (Том 1882). [020043] American Institute of Physics Inc.. https://doi.org/10.1063/1.5001622