The first experience of using 99mTc-Al2O3-based radiopharmaceutical for the detection of sentinel lymph nodes in cervical cancer patients

I. G. Sinilkin, V. I. Chernov, A. Yu Lyapunov, A. A. Medvedeva, R. V. Zelchan, A. L. Chernyshova, L. A. Kolomiets

Результат исследований: Материалы для книги/типы отчетовМатериалы для конференции

Аннотация

The purpose of the study was to evaluate the feasibility of using 99mTc-Al2O3-based radiopharmaceutical, a novel molecular imaging agent for sentinel lymph node detection in patients with invasive cervical cancer. The study included 23 cervical cancer patients (T1aNxMx-T2bNxMx) treated at the Tomsk Cancer Research Institute. In the 18 hours before surgery, 80 MBq of the 99mTc-Al2O3 in peritumoral injected, followed by single-photon emission computed tomography (SPECT) of the pelvis and intraoperative SLN identification. Twenty-seven SLNs were detected by SPECT, and 34 SLNs were identified by intraoperative gamma probe. The total number of identified SLNs per patient ranged from 1 to 3 (the mean number of SLNs was 1.4 per patient). The most common site for SLN detection was the external iliac region (57.2%), followed by the internal iliac (14%), obturator (14%), presacral and retrosacral regions (14%), and the parametrial region (1%). Sensitivity in detecting SLNs was 100% for intraoperative SLN identification and 79% for SPECT image.

Язык оригиналаАнглийский
Название основной публикацииPhysics of Cancer
Подзаголовок основной публикацииInterdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016
РедакторыYurii P. Sharkeev, Oleg B. Naimark, Elazar Y. Gutmanas
ИздательAmerican Institute of Physics Inc.
ISBN (электронное издание)9780735414181
DOI
СостояниеОпубликовано - 2 авг 2016
СобытиеInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016, PC 2016 - Tomsk, Российская Федерация
Продолжительность: 22 мар 201625 мар 2016

Серия публикаций

НазваниеAIP Conference Proceedings
Том1760
ISSN (печатное издание)0094-243X
ISSN (электронное издание)1551-7616

Конференция

КонференцияInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016, PC 2016
СтранаРоссийская Федерация
ГородTomsk
Период22.3.1625.3.16

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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