TY - JOUR
T1 - The effect of Katp channel activation on the electrical stability of myocardium in rats with postinfarction cardiosclerosis
AU - Solenkova, N. V.
AU - Maslov, L. N.
AU - Serebrov, Vladimir Yurievich
AU - Lishmanov, Yury Borisovich
AU - Bogomaz, S. A.
AU - Gross, G. J.
AU - Grover, G. J.
PY - 2004
Y1 - 2004
N2 - Opening of the ATP-dependent K-channels (KATP channels) upon intravenous administration of the cardioselective activator BMS 180448 (3 mg/kg) decreased the ventricular fibrillation threshold (VFT) in rats with postinfarction cardiosclerosis (PIC). Preliminary injection of the selective KATP channel blocker glibenclamide (0.3 mg/kg, i.v.) completely abolished the profibrillatory effect of BMS 180448. At the same time, the mitochondrial KATP channel blocker 5-hydroxydecanoic acid (5 mg/kg) did not influence the proarrhythmogen activity of BMS 180448. Simultaneous administration of the sarcoKATP channel inhibitor HMR 1098 (3 mg/kg) and BMS 180448 increased the VFT up to a level in intact animals. Administration of the mitoKATP channel activator diazoxide (5 mg/kg) after preliminary treatment with guanethidine (50 mg/kg) increased the VFT in rats with PIC. It is concluded that opening of the mitoKATP channels increases the cardiac electrical stability in rats with PIC.
AB - Opening of the ATP-dependent K-channels (KATP channels) upon intravenous administration of the cardioselective activator BMS 180448 (3 mg/kg) decreased the ventricular fibrillation threshold (VFT) in rats with postinfarction cardiosclerosis (PIC). Preliminary injection of the selective KATP channel blocker glibenclamide (0.3 mg/kg, i.v.) completely abolished the profibrillatory effect of BMS 180448. At the same time, the mitochondrial KATP channel blocker 5-hydroxydecanoic acid (5 mg/kg) did not influence the proarrhythmogen activity of BMS 180448. Simultaneous administration of the sarcoKATP channel inhibitor HMR 1098 (3 mg/kg) and BMS 180448 increased the VFT up to a level in intact animals. Administration of the mitoKATP channel activator diazoxide (5 mg/kg) after preliminary treatment with guanethidine (50 mg/kg) increased the VFT in rats with PIC. It is concluded that opening of the mitoKATP channels increases the cardiac electrical stability in rats with PIC.
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M3 - Article
C2 - 15341059
AN - SCOPUS:3142676341
VL - 67
SP - 10
EP - 13
JO - Eksperimental'naya i Klinicheskaya Farmakologiya
JF - Eksperimental'naya i Klinicheskaya Farmakologiya
SN - 0869-2092
IS - 3
ER -