The correlation between schizophrenia duration and the serum concentration of dehydroepiandrosterone sulfate

Результат исследований: Материалы для журналаСтатья

1 Цитирования (Scopus)

Аннотация

Dehydroepiandrosterone sulfate (DHEAS) is an important neurosteroid that has numerous functions in the central nervous system. It may be involved in the pathophysiological processes in schizophrenia. We investigated the serum DHEAS levels in 182 schizophrenic patients and related it to the duration of the schizophrenia. We found that schizophrenic patients have lower serum DHEAS concentrations as compared to healthy subjects. We also found sex-related differences in the serum DHEAS concentrations. Men have higher DHEAS levels compared to women in both the healthy and schizophrenic groups. We found a correlation between the illness duration and a decrease in the serum DHEAS concentrations in schizophrenic patients. The decrease in the serum DHEAS concentrations in schizophrenic patients theoretically may contribute to a dopaminergic and glutamatergic imbalance that leads the development of psychotic symptoms and cognitive dysfunction.

Язык оригиналаАнглийский
Страницы (с-по)290-293
Число страниц4
ЖурналNeurochemical Journal
Том5
Номер выпуска4
DOI
СостояниеОпубликовано - дек 2011

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Molecular Biology
  • Biochemistry

Fingerprint Подробные сведения о темах исследования «The correlation between schizophrenia duration and the serum concentration of dehydroepiandrosterone sulfate». Вместе они формируют уникальный семантический отпечаток (fingerprint).

  • Цитировать