The anti-arrhythmic effect of d-Ala 2, Leu 5, Arg 6-enkephalin and its possible mechanism

Leonid N. Maslov, Yury B. Lishmanov

Результат исследований: Материалы для журналаСтатьярецензирование

41 Цитирования (Scopus)

Аннотация

We studied antiarrhythmic action of d-Ala 2, Leu 5, Arg 6-enkephalin (dalargin) in experiments on male rats. Dalargin is reported to prevent heart rhythm disturbance and heart electrical stability decrease in experimental coronary occlusion, postinfarction, cardiosclerosis and emotional stress. Dalargin prevents acute myocardial ischaemia-induced increase of cAMP content in blood serum and cardiac muscle, as an indirect feature of its antiadrenergic activity. d-Ala 2, Leu 5, Arg 6-enkephalin leads to a decrease of cAMP content in myocardium and blood plasma, which presumably indicates a decrease of sympathetic tone. The data strongly suggest that cGMP content increase and somatostatin level decrease in cardiac muscle play a significant role in antiarrhythmic action of dalargin.

Язык оригиналаАнглийский
Страницы (с-по)89-94
Число страниц6
ЖурналInternational Journal of Cardiology
Том40
Номер выпуска2
DOI
СостояниеОпубликовано - 1 июл 1993

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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