Temperature-responsive PLLA/PNIPAM nanofibers for switchable release

Roman Elashnikov, Petr Slepička, Silvie Rimpelova, Pavel Ulbrich, Vaclav Švorčík, Oleksiy Lyutakov

Результат исследований: Материалы для журналаСтатьярецензирование

33 Цитирования (Scopus)

Аннотация

Smart antimicrobial materials with on-demand drug release are highly desired for biomedical applications. Herein, we report about temperature-responsive poly(N-isopropylacrylamide) (PNIPAM) nanospheres doped with crystal violet (CV) and incorporated into the poly-L-lactide (PLLA) nanofibers. The nanofibers were prepared by electrospinning, using different initial polymers ratios. The morphology of the nanofibers and polymers distribution in the nanofibers were characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The interaction between PNIPAM and PLLA in the nanofibers was studied by Fourier transform infrared spectroscopy (FTIR) and its effect on the PNIPAM phase transition was also investigated. It was shown that by the changing of the environmental temperature across the lower critical solution temperature (LCST) of PNIPAM, the switchable wettability and controlled CV release can be achieved. The temperature-dependent release kinetics of CV from polymer nanofibers was investigated by ultraviolet-visible spectroscopy (UV–Vis). The temperature-responsive release of antibacterial CV was also tested for triggering of antibacterial activity, which was examined on Staphylococcus epidermidis (S. epidermidis) and Escherichia coli (E. coli). Thus, the proposed material is promising value for controllable drug-release.

Язык оригиналаАнглийский
Страницы (с-по)293-300
Число страниц8
ЖурналMaterials Science and Engineering C
Том72
DOI
СостояниеОпубликовано - 1 мар 2017
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Fingerprint Подробные сведения о темах исследования «Temperature-responsive PLLA/PNIPAM nanofibers for switchable release». Вместе они формируют уникальный семантический отпечаток (fingerprint).

Цитировать