Synthetic and mechanistic aspects of cross-coupling of nitroxyl radicals of 3-imidazoline series with terminal alkynes

Sergei F. Vasilevsky, Olga L. Krivenko, Vitalii R. Gorelik, Igor V. Alabugin

Результат исследований: Материалы для журналаСтатьярецензирование

2 Цитирования (Scopus)

Аннотация

Practical synthetic approaches to the new class of acetylenic derivatives of 3-imidazolyl-3-oxide-1-oxyls, including biradicals, were developed through cross-coupling reactions of 3-imidazolyl halides with either terminal alkynes or their copper salts. The presence of nitroxyl functional group as an internal oxidant leads to a competition between the formation of cross-coupling products and the products of oxidative homocoupling. The balance in this competition can be shifted toward the cross-coupling products through the combination of factors that includes nature of the catalyst, reactivity of the halides, and reaction conditions.

Язык оригиналаАнглийский
Страницы (с-по)8807-8814
Число страниц8
ЖурналTetrahedron
Том64
Номер выпуска37
DOI
СостояниеОпубликовано - 8 сен 2008
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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