A highly regioselective synthetic method based on the domino Diels-Alder/retro-Diels-Alder reaction (DA/RDA) of 1,3-dienic δ-sultones with alkynes provides substituted m-terphenyls by elimination of SO3. A variety of δ-sultones and alkynes were examined to determine the scope of the reaction. The de novo synthesized aromatic products were obtained using thermal, microwave, and high-pressure activation.
ASJC Scopus subject areas
- Organic Chemistry