TY - JOUR
T1 - Synthesis of 7-aza-5-deazapurine analogues via copper(I)-catalyzed hydroamination of alkynes and 1-iodoalkynes
AU - Krasnova, Larissa B.
AU - Hein, Jason E.
AU - Fokin, Valery V.
PY - 2010/12/17
Y1 - 2010/12/17
N2 - A new method for the synthesis of dihydroimidazo[1,2-a][1,3,5]triazin-4(6H) -ones via copper(I)-catalyzed hydroamination was developed. In addition, for the first time, iodoalkynes were shown to participate in the copper(I)-catalyzed intramolecular hydroamination reaction with exclusive formation of E-isomers.
AB - A new method for the synthesis of dihydroimidazo[1,2-a][1,3,5]triazin-4(6H) -ones via copper(I)-catalyzed hydroamination was developed. In addition, for the first time, iodoalkynes were shown to participate in the copper(I)-catalyzed intramolecular hydroamination reaction with exclusive formation of E-isomers.
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U2 - 10.1021/jo1016376
DO - 10.1021/jo1016376
M3 - Article
C2 - 21105687
AN - SCOPUS:78650369357
VL - 75
SP - 8662
EP - 8665
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
SN - 0022-3263
IS - 24
ER -