Synthesis of 1,4-triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B

Benjamin H. Fraser, Stephanie Hamilton, Anwen M. Krause-Heuer, Philip J. Wright, Ivan Greguric, Simon P. Tucker, Alistair G. Draffan, Valery V. Fokin, K. Barry Sharpless

Результат исследований: Материалы для журнала › Статья › рецензирование

15 Цитирования (Scopus)

Аннотация

The copper catalyzed azide alkyne cycloaddition (CuAAC) reaction-the quintessential 'click' reaction-was used to synthesise dimers of the neuraminidase inhibitor zanamivir in high yields. The effect upon anti-viral activity of varying the linker length and the number of triazole units was explored. All dimers were tested for anti-viral activity against influenza A/Sydney/5/97 and B/Harbin/7/94 in a cytopathic effect (CPE) assay.

Язык оригинала	Английский
Страницы (с-по)	383-386
Число страниц	4
Журнал	MedChemComm
Том	4
Номер выпуска	2
DOI	https://doi.org/10.1039/c2md20300f
Состояние	Опубликовано - 2013
Опубликовано для внешнего пользования	Да

ASJC Scopus subject areas

Biochemistry
Pharmaceutical Science

Доступ к документу

10.1039/c2md20300f

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Цитировать

Synthesis of 1,4-triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B. / Fraser, Benjamin H.; Hamilton, Stephanie; Krause-Heuer, Anwen M.; Wright, Philip J.; Greguric, Ivan; Tucker, Simon P.; Draffan, Alistair G.; Fokin, Valery V.; Sharpless, K. Barry.

В: MedChemComm, Том 4, № 2, 2013, стр. 383-386.

Результат исследований: Материалы для журнала › Статья › рецензирование

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AU - Greguric, Ivan

AU - Tucker, Simon P.

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