Synthesis and biological characterization of 123I-labeled 15-(p-iodophenyl)-3-methylpentadecanoic acid

Yu N. Takhauova, V. S. Skuridin, B. K. Kudelin, V. M. Golovkov, Natalia Valerievna Varlamova, E. V. Makarova, V. I. Chernov

Результат исследований: Материалы для журналаСтатья

2 Цитирования (Scopus)

Аннотация

Experimental batches of iodine-123-labeled beta-methyl iodophenylpentadecanoic acid (123I-BMIPP) with an activity of 180 MBq/mL have been produced based on 123I extracted from enriched 122Te targets irradiated by accelerated deuterons at the R-7M cyclotron. It is shown that the radiochemical purity of 123I-BMIPP in EtOH solutions exceeds 96% at an acceptable content of the main chemical impurities (Cu, Te). The conditions of 123I-BMIPP dilution in human serum albumin (10%) solution for injection in experimental animals are determined. The biological behavior of the preparation in rats has been studied. It is established that 123I-BMIPP is characterized by pronounced accumulation in the heart. A qualitative scintigram of the rabbit heart was obtained and showed the possibility of external detection. It is established that it is possible to judge the viability of myocardium by measuring the amount of 123I-BMIPP accumulated in the heart.

Язык оригиналаАнглийский
Страницы (с-по)521-524
Число страниц4
ЖурналPharmaceutical Chemistry Journal
Том43
Номер выпуска9
DOI
СостояниеОпубликовано - сен 2009

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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