Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide

O. A. Nurkenov, Zh B. Satpaeva, I. A. Schepetkin, A. I. Khlebnikov, K. M. Turdybekov, T. M. Seilkhanov, S. D. Fazylov

Результат исследований: Материалы для журналаСтатья

1 цитирование (Scopus)

Выдержка

A series of hydrazones based on hydrazides of o- and p-hydroxybenzoic acids have been prepared. N-(5-Bromo-2-hydroxybenzylidene)-4-hydroxybenzohydrazide has been studied by X-ray diffraction analysis; its molecule forms hydrogen bond with a solvating ethanol molecule. Biological activity of the synthesized hydrazones towards cathepsin Е and(or) elastase of human neutrophils has been determined.

Язык оригиналаАнглийский
Страницы (с-по)2299-2306
Число страниц8
ЖурналRussian Journal of General Chemistry
Том87
Номер выпуска10
DOI
СостояниеОпубликовано - 1 окт 2017

Отпечаток

Hydroxybenzoates
Hydrazones
Bioactivity
Cathepsins
Molecules
Pancreatic Elastase
X ray diffraction analysis
Hydrogen bonds
Ethanol
4-hydroxybenzoic acid hydrazide

ASJC Scopus subject areas

  • Chemistry(all)

Цитировать

Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide. / Nurkenov, O. A.; Satpaeva, Zh B.; Schepetkin, I. A.; Khlebnikov, A. I.; Turdybekov, K. M.; Seilkhanov, T. M.; Fazylov, S. D.

В: Russian Journal of General Chemistry, Том 87, № 10, 01.10.2017, стр. 2299-2306.

Результат исследований: Материалы для журналаСтатья

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abstract = "A series of hydrazones based on hydrazides of o- and p-hydroxybenzoic acids have been prepared. N-(5-Bromo-2-hydroxybenzylidene)-4-hydroxybenzohydrazide has been studied by X-ray diffraction analysis; its molecule forms hydrogen bond with a solvating ethanol molecule. Biological activity of the synthesized hydrazones towards cathepsin Е and(or) elastase of human neutrophils has been determined.",
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author = "Nurkenov, {O. A.} and Satpaeva, {Zh B.} and Schepetkin, {I. A.} and Khlebnikov, {A. I.} and Turdybekov, {K. M.} and Seilkhanov, {T. M.} and Fazylov, {S. D.}",
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AU - Nurkenov, O. A.

AU - Satpaeva, Zh B.

AU - Schepetkin, I. A.

AU - Khlebnikov, A. I.

AU - Turdybekov, K. M.

AU - Seilkhanov, T. M.

AU - Fazylov, S. D.

PY - 2017/10/1

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KW - cathepsin Е

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KW - hydroxybenzoic acid hydrazide

KW - molecular docking

KW - neutrophil elastase

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