TY - JOUR
T1 - Surface modification of electrospun poly-(L-lactic) acid scaffolds by reactive magnetron sputtering
AU - Bolbasov, E. N.
AU - Maryin, P. V.
AU - Stankevich, K. S.
AU - Kozelskaya, A. I.
AU - Shesterikov, E. V.
AU - Khodyrevskaya, Yu I.
AU - Nasonova, M. V.
AU - Shishkova, D. K.
AU - Kudryavtseva, Yu A.
AU - Anissimov, Y. G.
AU - Tverdokhlebov, S. I.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - In this study, we modified the surface of bioresorbable electrospun poly-(L-lactic) acid (PLLA) scaffolds by reactive magnetron sputtering of a titanium target under a nitrogen atmosphere. We examined the influence of the plasma treatment time on the structure and properties of electrospun PLLA scaffolds using SEM, XRF, FTIR, XRD, optical goniometry, and mechanical testing. It was observed that the coating formed did not change physicomechanical properties of electrospun PLLA scaffolds and simultaneously, increased their hydrophilicity. No adverse tissue reaction up to 3 months after subcutaneous implantation of the modified scaffolds was detected in in-vivo rat model. The rate of scaffold replacement by the recipient tissue in-vivo was observed to depend on the plasma treatment time.
AB - In this study, we modified the surface of bioresorbable electrospun poly-(L-lactic) acid (PLLA) scaffolds by reactive magnetron sputtering of a titanium target under a nitrogen atmosphere. We examined the influence of the plasma treatment time on the structure and properties of electrospun PLLA scaffolds using SEM, XRF, FTIR, XRD, optical goniometry, and mechanical testing. It was observed that the coating formed did not change physicomechanical properties of electrospun PLLA scaffolds and simultaneously, increased their hydrophilicity. No adverse tissue reaction up to 3 months after subcutaneous implantation of the modified scaffolds was detected in in-vivo rat model. The rate of scaffold replacement by the recipient tissue in-vivo was observed to depend on the plasma treatment time.
KW - Biocompatibility
KW - Electrospun PLLA scaffold
KW - Reactive magnetron sputtering
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U2 - 10.1016/j.colsurfb.2017.11.028
DO - 10.1016/j.colsurfb.2017.11.028
M3 - Article
AN - SCOPUS:85034058623
VL - 162
SP - 43
EP - 51
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
SN - 0927-7765
ER -