Surface modification of electrospun poly-(L-lactic) acid scaffolds by reactive magnetron sputtering

E. N. Bolbasov, P. V. Maryin, K. S. Stankevich, A. I. Kozelskaya, E. V. Shesterikov, Yu I. Khodyrevskaya, M. V. Nasonova, D. K. Shishkova, Yu A. Kudryavtseva, Y. G. Anissimov, S. I. Tverdokhlebov

Научно-образовательный центр Б.П. Вейнберга

Результат исследований: Материалы для журнала › Статья

12 Цитирования (Scopus)

Аннотация

In this study, we modified the surface of bioresorbable electrospun poly-(L-lactic) acid (PLLA) scaffolds by reactive magnetron sputtering of a titanium target under a nitrogen atmosphere. We examined the influence of the plasma treatment time on the structure and properties of electrospun PLLA scaffolds using SEM, XRF, FTIR, XRD, optical goniometry, and mechanical testing. It was observed that the coating formed did not change physicomechanical properties of electrospun PLLA scaffolds and simultaneously, increased their hydrophilicity. No adverse tissue reaction up to 3 months after subcutaneous implantation of the modified scaffolds was detected in in-vivo rat model. The rate of scaffold replacement by the recipient tissue in-vivo was observed to depend on the plasma treatment time.

Язык оригинала	Английский
Страницы (с-по)	43-51
Число страниц	9
Журнал	Colloids and Surfaces B: Biointerfaces
Том	162
DOI	https://doi.org/10.1016/j.colsurfb.2017.11.028
Состояние	Опубликовано - 1 фев 2018

ASJC Scopus subject areas

Biotechnology
Surfaces and Interfaces
Physical and Theoretical Chemistry
Colloid and Surface Chemistry

Доступ к документу

10.1016/j.colsurfb.2017.11.028

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Цитировать

Bolbasov, E. N., Maryin, P. V., Stankevich, K. S., Kozelskaya, A. I., Shesterikov, E. V., Khodyrevskaya, Y. I., Nasonova, M. V., Shishkova, D. K., Kudryavtseva, Y. A., Anissimov, Y. G., & Tverdokhlebov, S. I. (2018). Surface modification of electrospun poly-(L-lactic) acid scaffolds by reactive magnetron sputtering. Colloids and Surfaces B: Biointerfaces, 162, 43-51. https://doi.org/10.1016/j.colsurfb.2017.11.028

Surface modification of electrospun poly-(L-lactic) acid scaffolds by reactive magnetron sputtering. / Bolbasov, E. N.; Maryin, P. V.; Stankevich, K. S.; Kozelskaya, A. I.; Shesterikov, E. V.; Khodyrevskaya, Yu I.; Nasonova, M. V.; Shishkova, D. K.; Kudryavtseva, Yu A.; Anissimov, Y. G.; Tverdokhlebov, S. I.

В: Colloids and Surfaces B: Biointerfaces, Том 162, 01.02.2018, стр. 43-51.

Результат исследований: Материалы для журнала › Статья

Bolbasov, EN, Maryin, PV, Stankevich, KS , Kozelskaya, AI , Shesterikov, EV, Khodyrevskaya, YI, Nasonova, MV, Shishkova, DK, Kudryavtseva, YA, Anissimov, YG & Tverdokhlebov, SI 2018, 'Surface modification of electrospun poly-(L-lactic) acid scaffolds by reactive magnetron sputtering', Colloids and Surfaces B: Biointerfaces, том. 162, стр. 43-51. https://doi.org/10.1016/j.colsurfb.2017.11.028

Bolbasov, E. N. ; Maryin, P. V. ; Stankevich, K. S. ; Kozelskaya, A. I. ; Shesterikov, E. V. ; Khodyrevskaya, Yu I. ; Nasonova, M. V. ; Shishkova, D. K. ; Kudryavtseva, Yu A. ; Anissimov, Y. G. ; Tverdokhlebov, S. I. / Surface modification of electrospun poly-(L-lactic) acid scaffolds by reactive magnetron sputtering. В: Colloids and Surfaces B: Biointerfaces. 2018 ; Том 162. стр. 43-51.

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abstract = "In this study, we modified the surface of bioresorbable electrospun poly-(L-lactic) acid (PLLA) scaffolds by reactive magnetron sputtering of a titanium target under a nitrogen atmosphere. We examined the influence of the plasma treatment time on the structure and properties of electrospun PLLA scaffolds using SEM, XRF, FTIR, XRD, optical goniometry, and mechanical testing. It was observed that the coating formed did not change physicomechanical properties of electrospun PLLA scaffolds and simultaneously, increased their hydrophilicity. No adverse tissue reaction up to 3 months after subcutaneous implantation of the modified scaffolds was detected in in-vivo rat model. The rate of scaffold replacement by the recipient tissue in-vivo was observed to depend on the plasma treatment time.",

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AU - Bolbasov, E. N.

AU - Maryin, P. V.

AU - Stankevich, K. S.

AU - Kozelskaya, A. I.

AU - Shesterikov, E. V.

AU - Khodyrevskaya, Yu I.

AU - Nasonova, M. V.

AU - Shishkova, D. K.

AU - Kudryavtseva, Yu A.

AU - Anissimov, Y. G.

AU - Tverdokhlebov, S. I.

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N2 - In this study, we modified the surface of bioresorbable electrospun poly-(L-lactic) acid (PLLA) scaffolds by reactive magnetron sputtering of a titanium target under a nitrogen atmosphere. We examined the influence of the plasma treatment time on the structure and properties of electrospun PLLA scaffolds using SEM, XRF, FTIR, XRD, optical goniometry, and mechanical testing. It was observed that the coating formed did not change physicomechanical properties of electrospun PLLA scaffolds and simultaneously, increased their hydrophilicity. No adverse tissue reaction up to 3 months after subcutaneous implantation of the modified scaffolds was detected in in-vivo rat model. The rate of scaffold replacement by the recipient tissue in-vivo was observed to depend on the plasma treatment time.

AB - In this study, we modified the surface of bioresorbable electrospun poly-(L-lactic) acid (PLLA) scaffolds by reactive magnetron sputtering of a titanium target under a nitrogen atmosphere. We examined the influence of the plasma treatment time on the structure and properties of electrospun PLLA scaffolds using SEM, XRF, FTIR, XRD, optical goniometry, and mechanical testing. It was observed that the coating formed did not change physicomechanical properties of electrospun PLLA scaffolds and simultaneously, increased their hydrophilicity. No adverse tissue reaction up to 3 months after subcutaneous implantation of the modified scaffolds was detected in in-vivo rat model. The rate of scaffold replacement by the recipient tissue in-vivo was observed to depend on the plasma treatment time.

KW - Biocompatibility

KW - Electrospun PLLA scaffold

KW - Reactive magnetron sputtering

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