Выдержка
Stents are important medical devices used to increase the quality and life expectancy of patients with heart diseases and stroke, leading causes of death, worldwide. In order to minimize the risk of restenosis, different coating on bare metal stents (BMS) such as polymer coatings; titanium dioxide, titanium nitride or titanium oxynitride coatings; carbon coatings and others are used. The aim of this work was to develop novel stents coated with titanium oxynitride (TiOxNy) with optimal chemical, mechanical and biological properties having possibly good coverage rate of inner and outer stent surfaces. The improvement should be achieved by optimization and development of a magnetron sputtering deposition technology. The goal of the study is understanding of the existing potential for improvement of the deposition technology and the coating quality itself. For this study, different O2/N2 ratios, meaning 1/2, 1/5 and 1/10 (the ratios of reagent gasses are given for the values of mass flows into the chamber) has been selected. Stability in simulated body fluids, surface morphology and protein adsorption as well as preliminary cytotoxic behaviour of the samples on HUVEC cells has been analysed. SEM experiments have shown the potential in the improvement of coating-stent adhesion by all samples. TiOxNy 1:5 samples were found to have the lowest adsorption, the smoothest surface morphology and the smallest rate of salt deposition from simulated body fluids (SBFs). This kind of surface has been recommended for further optimization and application.
| Язык оригинала | Английский |
|---|---|
| Страницы (с-по) | 405-416 |
| Число страниц | 12 |
| Журнал | Materials Science and Engineering C |
| Том | 99 |
| DOI | |
| Состояние | Опубликовано - 1 июн 2019 |
Отпечаток
ASJC Scopus subject areas
- Materials Science(all)
- Condensed Matter Physics
- Mechanics of Materials
- Mechanical Engineering
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Surface evaluation of titanium oxynitride coatings used for developing layered cardiovascular stents. / Beshchasna, Nataliia; Ho, Au Yeung Kwan; Saqib, Muhammad; Kraśkiewicz, Honorata; Wasyluk, Łukasz; Kuzmin, Oleg; Duta, Oana Cristina; Ficai, Denisa; Trusca, Roxana Doina; Ficai, Anton; Pichugin, Vladimir F.; Opitz, Jörg; Andronescu, Ecaterina.
В: Materials Science and Engineering C, Том 99, 01.06.2019, стр. 405-416.Результат исследований: Материалы для журнала › Статья
}
TY - JOUR
T1 - Surface evaluation of titanium oxynitride coatings used for developing layered cardiovascular stents
AU - Beshchasna, Nataliia
AU - Ho, Au Yeung Kwan
AU - Saqib, Muhammad
AU - Kraśkiewicz, Honorata
AU - Wasyluk, Łukasz
AU - Kuzmin, Oleg
AU - Duta, Oana Cristina
AU - Ficai, Denisa
AU - Trusca, Roxana Doina
AU - Ficai, Anton
AU - Pichugin, Vladimir F.
AU - Opitz, Jörg
AU - Andronescu, Ecaterina
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Stents are important medical devices used to increase the quality and life expectancy of patients with heart diseases and stroke, leading causes of death, worldwide. In order to minimize the risk of restenosis, different coating on bare metal stents (BMS) such as polymer coatings; titanium dioxide, titanium nitride or titanium oxynitride coatings; carbon coatings and others are used. The aim of this work was to develop novel stents coated with titanium oxynitride (TiOxNy) with optimal chemical, mechanical and biological properties having possibly good coverage rate of inner and outer stent surfaces. The improvement should be achieved by optimization and development of a magnetron sputtering deposition technology. The goal of the study is understanding of the existing potential for improvement of the deposition technology and the coating quality itself. For this study, different O2/N2 ratios, meaning 1/2, 1/5 and 1/10 (the ratios of reagent gasses are given for the values of mass flows into the chamber) has been selected. Stability in simulated body fluids, surface morphology and protein adsorption as well as preliminary cytotoxic behaviour of the samples on HUVEC cells has been analysed. SEM experiments have shown the potential in the improvement of coating-stent adhesion by all samples. TiOxNy 1:5 samples were found to have the lowest adsorption, the smoothest surface morphology and the smallest rate of salt deposition from simulated body fluids (SBFs). This kind of surface has been recommended for further optimization and application.
AB - Stents are important medical devices used to increase the quality and life expectancy of patients with heart diseases and stroke, leading causes of death, worldwide. In order to minimize the risk of restenosis, different coating on bare metal stents (BMS) such as polymer coatings; titanium dioxide, titanium nitride or titanium oxynitride coatings; carbon coatings and others are used. The aim of this work was to develop novel stents coated with titanium oxynitride (TiOxNy) with optimal chemical, mechanical and biological properties having possibly good coverage rate of inner and outer stent surfaces. The improvement should be achieved by optimization and development of a magnetron sputtering deposition technology. The goal of the study is understanding of the existing potential for improvement of the deposition technology and the coating quality itself. For this study, different O2/N2 ratios, meaning 1/2, 1/5 and 1/10 (the ratios of reagent gasses are given for the values of mass flows into the chamber) has been selected. Stability in simulated body fluids, surface morphology and protein adsorption as well as preliminary cytotoxic behaviour of the samples on HUVEC cells has been analysed. SEM experiments have shown the potential in the improvement of coating-stent adhesion by all samples. TiOxNy 1:5 samples were found to have the lowest adsorption, the smoothest surface morphology and the smallest rate of salt deposition from simulated body fluids (SBFs). This kind of surface has been recommended for further optimization and application.
KW - Biological assessments
KW - Cardiovascular stent, surface evaluation
KW - Magnetron sputtering
KW - Protein adsorption
KW - Static and dynamic evaluation in simulated body fluids, electrochemical evaluation
KW - Titanium oxynitride coating
UR - http://www.scopus.com/inward/record.url?scp=85060849826&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85060849826&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2019.01.131
DO - 10.1016/j.msec.2019.01.131
M3 - Article
AN - SCOPUS:85060849826
VL - 99
SP - 405
EP - 416
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
SN - 0928-4931
ER -