Surface evaluation of titanium oxynitride coatings used for developing layered cardiovascular stents

Nataliia Beshchasna, Au Yeung Kwan Ho, Muhammad Saqib, Honorata Kraśkiewicz, Łukasz Wasyluk, Oleg Kuzmin, Oana Cristina Duta, Denisa Ficai, Roxana Doina Trusca, Anton Ficai, Vladimir F. Pichugin, Jörg Opitz, Ecaterina Andronescu

Результат исследований: Материалы для журналаСтатья

4 Цитирования (Scopus)

Аннотация

Stents are important medical devices used to increase the quality and life expectancy of patients with heart diseases and stroke, leading causes of death, worldwide. In order to minimize the risk of restenosis, different coating on bare metal stents (BMS) such as polymer coatings; titanium dioxide, titanium nitride or titanium oxynitride coatings; carbon coatings and others are used. The aim of this work was to develop novel stents coated with titanium oxynitride (TiOxNy) with optimal chemical, mechanical and biological properties having possibly good coverage rate of inner and outer stent surfaces. The improvement should be achieved by optimization and development of a magnetron sputtering deposition technology. The goal of the study is understanding of the existing potential for improvement of the deposition technology and the coating quality itself. For this study, different O2/N2 ratios, meaning 1/2, 1/5 and 1/10 (the ratios of reagent gasses are given for the values of mass flows into the chamber) has been selected. Stability in simulated body fluids, surface morphology and protein adsorption as well as preliminary cytotoxic behaviour of the samples on HUVEC cells has been analysed. SEM experiments have shown the potential in the improvement of coating-stent adhesion by all samples. TiOxNy 1:5 samples were found to have the lowest adsorption, the smoothest surface morphology and the smallest rate of salt deposition from simulated body fluids (SBFs). This kind of surface has been recommended for further optimization and application.

Язык оригиналаАнглийский
Страницы (с-по)405-416
Число страниц12
ЖурналMaterials Science and Engineering C
Том99
DOI
СостояниеОпубликовано - 1 июн 2019

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ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Цитировать

Beshchasna, N., Ho, A. Y. K., Saqib, M., Kraśkiewicz, H., Wasyluk, Ł., Kuzmin, O., Duta, O. C., Ficai, D., Trusca, R. D., Ficai, A., Pichugin, V. F., Opitz, J., & Andronescu, E. (2019). Surface evaluation of titanium oxynitride coatings used for developing layered cardiovascular stents. Materials Science and Engineering C, 99, 405-416. https://doi.org/10.1016/j.msec.2019.01.131