Suppression by radiosensitizer AK-2123 of early phorbol myristate acetate-stimulated chemiluminescence response of human neutrophils induced by gamma-irradiation (short communication)

Результат исследований: Материалы для журналаСтатья

2 Цитирования (Scopus)

Выдержка

The influence of γ-irradiation and radiosensitizer AK-2123 on secretion of reactive oxygen species (ROS) of human neutrophils was studied, γ- irradiation (from 5 to 25 Gy) of the neutrophil suspension inhibited spontaneous chemiluminescence and activated phorbol-12-myristate-13-acetate (PMA)-stimulated chemiluminescence. The time of maximum PMA-stimulated chemiluminescence amplitude was decreased with the dose range from 2 to 25 Gy. The addition of radiosensitizer AK-2123 depressed the early PMA- stimulated chemiluminescence response to γ-irradiation. The obtained results suggest that this effect is connected with influence of AK-2123 on ion canals of neutrophils and may prevent the radiation-induced damage of blood cells.

Язык оригиналаАнглийский
Страницы (с-по)453-456
Число страниц4
ЖурналCancer Biotherapy and Radiopharmaceuticals
Том13
Номер выпуска6
СостояниеОпубликовано - 1998
Опубликовано для внешнего пользованияДа

Отпечаток

Tetradecanoylphorbol Acetate
Luminescence
Neutrophils
Communication
Acetates
Reactive Oxygen Species
Blood Cells
Suspensions
Ions
Radiation
AK 2123
phorbol-12-myristate

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pharmacology

Цитировать

@article{62ba4ad265f04067903a42833302cd98,
title = "Suppression by radiosensitizer AK-2123 of early phorbol myristate acetate-stimulated chemiluminescence response of human neutrophils induced by gamma-irradiation (short communication)",
abstract = "The influence of γ-irradiation and radiosensitizer AK-2123 on secretion of reactive oxygen species (ROS) of human neutrophils was studied, γ- irradiation (from 5 to 25 Gy) of the neutrophil suspension inhibited spontaneous chemiluminescence and activated phorbol-12-myristate-13-acetate (PMA)-stimulated chemiluminescence. The time of maximum PMA-stimulated chemiluminescence amplitude was decreased with the dose range from 2 to 25 Gy. The addition of radiosensitizer AK-2123 depressed the early PMA- stimulated chemiluminescence response to γ-irradiation. The obtained results suggest that this effect is connected with influence of AK-2123 on ion canals of neutrophils and may prevent the radiation-induced damage of blood cells.",
keywords = "γ-irradiation, Neutrophils, Radiosensitizer, Reactive oxygen species",
author = "Igor Schepetkin",
year = "1998",
language = "English",
volume = "13",
pages = "453--456",
journal = "Cancer Biotherapy and Radiopharmaceuticals",
issn = "1084-9785",
publisher = "Mary Ann Liebert Inc.",
number = "6",

}

TY - JOUR

T1 - Suppression by radiosensitizer AK-2123 of early phorbol myristate acetate-stimulated chemiluminescence response of human neutrophils induced by gamma-irradiation (short communication)

AU - Schepetkin, Igor

PY - 1998

Y1 - 1998

N2 - The influence of γ-irradiation and radiosensitizer AK-2123 on secretion of reactive oxygen species (ROS) of human neutrophils was studied, γ- irradiation (from 5 to 25 Gy) of the neutrophil suspension inhibited spontaneous chemiluminescence and activated phorbol-12-myristate-13-acetate (PMA)-stimulated chemiluminescence. The time of maximum PMA-stimulated chemiluminescence amplitude was decreased with the dose range from 2 to 25 Gy. The addition of radiosensitizer AK-2123 depressed the early PMA- stimulated chemiluminescence response to γ-irradiation. The obtained results suggest that this effect is connected with influence of AK-2123 on ion canals of neutrophils and may prevent the radiation-induced damage of blood cells.

AB - The influence of γ-irradiation and radiosensitizer AK-2123 on secretion of reactive oxygen species (ROS) of human neutrophils was studied, γ- irradiation (from 5 to 25 Gy) of the neutrophil suspension inhibited spontaneous chemiluminescence and activated phorbol-12-myristate-13-acetate (PMA)-stimulated chemiluminescence. The time of maximum PMA-stimulated chemiluminescence amplitude was decreased with the dose range from 2 to 25 Gy. The addition of radiosensitizer AK-2123 depressed the early PMA- stimulated chemiluminescence response to γ-irradiation. The obtained results suggest that this effect is connected with influence of AK-2123 on ion canals of neutrophils and may prevent the radiation-induced damage of blood cells.

KW - γ-irradiation

KW - Neutrophils

KW - Radiosensitizer

KW - Reactive oxygen species

UR - http://www.scopus.com/inward/record.url?scp=0032417117&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032417117&partnerID=8YFLogxK

M3 - Article

C2 - 10851438

AN - SCOPUS:0032417117

VL - 13

SP - 453

EP - 456

JO - Cancer Biotherapy and Radiopharmaceuticals

JF - Cancer Biotherapy and Radiopharmaceuticals

SN - 1084-9785

IS - 6

ER -