Suppression by radiosensitizer AK-2123 of early phorbol myristate acetate-stimulated chemiluminescence response of human neutrophils induced by gamma-irradiation (short communication)

Результат исследований: Материалы для журналаСтатья

2 Цитирования (Scopus)

Аннотация

The influence of γ-irradiation and radiosensitizer AK-2123 on secretion of reactive oxygen species (ROS) of human neutrophils was studied, γ- irradiation (from 5 to 25 Gy) of the neutrophil suspension inhibited spontaneous chemiluminescence and activated phorbol-12-myristate-13-acetate (PMA)-stimulated chemiluminescence. The time of maximum PMA-stimulated chemiluminescence amplitude was decreased with the dose range from 2 to 25 Gy. The addition of radiosensitizer AK-2123 depressed the early PMA- stimulated chemiluminescence response to γ-irradiation. The obtained results suggest that this effect is connected with influence of AK-2123 on ion canals of neutrophils and may prevent the radiation-induced damage of blood cells.

Язык оригиналаАнглийский
Страницы (с-по)453-456
Число страниц4
ЖурналCancer Biotherapy and Radiopharmaceuticals
Том13
Номер выпуска6
СостояниеОпубликовано - 1998
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pharmacology

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