99mTc-labeled monosaccharide kits: development methods and quality control

Результат исследований: Материалы для журналаСтатьярецензирование

Аннотация

The paper presents the procedure for planning an experiment to create standard sets of reagents for a technetium-99m generator based on glucose derivatives. All stages are presented from researching the required quantities of a substance, a reducing agent, a stabilizer and auxiliary components to developing lyophilized kits and conducting quality control. The radiochemical purity of radiopharmaceuticals prepared on the basis of the developed kits ranged from 90.0 to 99.0%. We also showed the functional suitability of the developed preparations on C57B1/6j mice with an implanted malignant tumor - Lewis lung carcinoma.

Язык оригиналаАнглийский
Номер статьи5121
ЖурналScientific Reports
Том10
Номер выпуска1
DOI
СостояниеОпубликовано - 1 дек 2020

ASJC Scopus subject areas

  • General

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