Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, 99mTc-Al2O3

N. V. Varlamova, A. A. Churin, T. I. Fomina, L. A. Ermolaeva, T. V. Vetoshkina, T. Yu Dubskaya, T. Yu Lamzina, E. P. Fedorova, O. V. Neupokoeva, V. S. Skuridin, E. A. Nesterov, L. A. Larionova, V. I. Chernov

Результат исследований: Материалы для журналаСтатья

1 Цитирования (Scopus)

Аннотация

We studied toxicity of a new Russian radiopharmaceutical Nanocolloid, 99mTc-Al2O3. Tests for acute toxicity showed that this agent belongs to a class of moderate-toxicity substances and does not have cumulative properties. The evaluation of subchronic toxicity after subcutaneous injection of this product to rats (0.04, 0.2, and 0.4 ml/kg) and rabbits (0.02 and 0.2 ml/kg) for 7 days did not reveal changes in the general state, temperature, body weight, indices of the peripheral blood and bone marrow, functions of the heart, liver, kidneys, and nervous system, and morphological characteristics of the internal organs in animals. The drug does not produce a local irritant effect.

Язык оригиналаАнглийский
Страницы (с-по)371-373
Число страниц3
ЖурналBulletin of Experimental Biology and Medicine
Том161
Номер выпуска3
DOI
СостояниеОпубликовано - 1 июл 2016

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Цитировать

    Varlamova, N. V., Churin, A. A., Fomina, T. I., Ermolaeva, L. A., Vetoshkina, T. V., Dubskaya, T. Y., Lamzina, T. Y., Fedorova, E. P., Neupokoeva, O. V., Skuridin, V. S., Nesterov, E. A., Larionova, L. A., & Chernov, V. I. (2016). Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, 99mTc-Al2O3. Bulletin of Experimental Biology and Medicine, 161(3), 371-373. https://doi.org/10.1007/s10517-016-3416-0