Study of the allergizing properties of nanocolloid,99mTc–Al2O3 radiopharmaceutical in experiment

Natalia Valerievna Varlamova, Elena Sergeevna Stasyuk, A. A. Titskaya, Ivan Gennadievich Sinilkin, L. A. Larionova, E. Y. Sherstoboyev, E. S. Trofimova, A. A. Ligacheva, V. S. Skuridin

Результат исследований: Материалы для журналаСтатья

1 цитирование (Scopus)

Выдержка

The aim of the investigation was to assess the allergizing properties of a new nanocolloidal preparation based on aluminum gamma-oxide labeled by technetium-99m for scintigraphic and intraoperative detection of sentinel lymphatic nodes in experiment. Materials and Methods. A series of experiments was performed on 80 guinea pigs, 30 Balb/c mice, 40 CBA/CaLac mice and 70 outbred mice of both genders. To study allergenicity various doses of preparation were administered subcutaneously, intramuscularly, intravenously, intradermally as a single injection or by a course. Allergizing properties of the radiopharmaceutical were investigated according to the “Guidelines on the assessment of allergizing properties of drugs”Results. Administration of Nanocolloid,99mTc‒Al2O3 radiopharmaceutical did not result in the intensification of anaphylaxis systemic reaction in the animals of the examined groups relative to the control. A single injection did not cause inflammatory reaction to Concanavalin A in the examined animals. When guinea pigs were immunized by the preparation, no delayed allergic reaction was revealed. Studying sensitizing effect of the preparation by 20 skin applications no redness or edema of the skin at the site of application was observed. Conclusion. Nanocolloid,99mTc‒Al2O3 radiopharmaceutical in the studied doses and under the selected experimental conditions does not possess allergizing properties.

Язык оригиналаАнглийский
Страницы (с-по)72-76
Число страниц5
ЖурналSovremennye Tehnologii v Medicine
Том7
Номер выпуска4
DOI
СостояниеОпубликовано - 1 янв 2015

Отпечаток

Radiopharmaceuticals
Skin
Guinea Pigs
Animals
Inbred CBA Mouse
Injections
Aluminum Oxide
Experiments
Technetium
Anaphylaxis
Concanavalin A
Aluminum
Oxides
Edema
Hypersensitivity
Guidelines

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Цитировать

Study of the allergizing properties of nanocolloid,99mTc–Al2O3 radiopharmaceutical in experiment. / Varlamova, Natalia Valerievna; Stasyuk, Elena Sergeevna; Titskaya, A. A.; Sinilkin, Ivan Gennadievich; Larionova, L. A.; Sherstoboyev, E. Y.; Trofimova, E. S.; Ligacheva, A. A.; Skuridin, V. S.

В: Sovremennye Tehnologii v Medicine, Том 7, № 4, 01.01.2015, стр. 72-76.

Результат исследований: Материалы для журналаСтатья

Varlamova, Natalia Valerievna ; Stasyuk, Elena Sergeevna ; Titskaya, A. A. ; Sinilkin, Ivan Gennadievich ; Larionova, L. A. ; Sherstoboyev, E. Y. ; Trofimova, E. S. ; Ligacheva, A. A. ; Skuridin, V. S. / Study of the allergizing properties of nanocolloid,99mTc–Al2O3 radiopharmaceutical in experiment. В: Sovremennye Tehnologii v Medicine. 2015 ; Том 7, № 4. стр. 72-76.
@article{8b3f6ed262b44260af615c178c84eaac,
title = "Study of the allergizing properties of nanocolloid,99mTc–Al2O3 radiopharmaceutical in experiment",
abstract = "The aim of the investigation was to assess the allergizing properties of a new nanocolloidal preparation based on aluminum gamma-oxide labeled by technetium-99m for scintigraphic and intraoperative detection of sentinel lymphatic nodes in experiment. Materials and Methods. A series of experiments was performed on 80 guinea pigs, 30 Balb/c mice, 40 CBA/CaLac mice and 70 outbred mice of both genders. To study allergenicity various doses of preparation were administered subcutaneously, intramuscularly, intravenously, intradermally as a single injection or by a course. Allergizing properties of the radiopharmaceutical were investigated according to the “Guidelines on the assessment of allergizing properties of drugs”Results. Administration of Nanocolloid,99mTc‒Al2O3 radiopharmaceutical did not result in the intensification of anaphylaxis systemic reaction in the animals of the examined groups relative to the control. A single injection did not cause inflammatory reaction to Concanavalin A in the examined animals. When guinea pigs were immunized by the preparation, no delayed allergic reaction was revealed. Studying sensitizing effect of the preparation by 20 skin applications no redness or edema of the skin at the site of application was observed. Conclusion. Nanocolloid,99mTc‒Al2O3 radiopharmaceutical in the studied doses and under the selected experimental conditions does not possess allergizing properties.",
keywords = "Allergizing properties, Nanocolloid, Radiopharmaceuticals, Sentinel lymphatic node",
author = "Natalia Valerievna Varlamova and Elena Sergeevna Stasyuk and Titskaya, {A. A.} and Sinilkin, {Ivan Gennadievich} and Larionova, {L. A.} and Sherstoboyev, {E. Y.} and Trofimova, {E. S.} and Ligacheva, {A. A.} and Skuridin, {V. S.}",
year = "2015",
month = "1",
day = "1",
doi = "10.17691/stm2015.7.4.09",
language = "English",
volume = "7",
pages = "72--76",
journal = "Sovremennye Tehnologii v Medicine",
issn = "2076-4243",
publisher = "Nizhny Novgorod State Medical Academy of the Ministry of Health of the Russian Federation",
number = "4",

}

TY - JOUR

T1 - Study of the allergizing properties of nanocolloid,99mTc–Al2O3 radiopharmaceutical in experiment

AU - Varlamova, Natalia Valerievna

AU - Stasyuk, Elena Sergeevna

AU - Titskaya, A. A.

AU - Sinilkin, Ivan Gennadievich

AU - Larionova, L. A.

AU - Sherstoboyev, E. Y.

AU - Trofimova, E. S.

AU - Ligacheva, A. A.

AU - Skuridin, V. S.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The aim of the investigation was to assess the allergizing properties of a new nanocolloidal preparation based on aluminum gamma-oxide labeled by technetium-99m for scintigraphic and intraoperative detection of sentinel lymphatic nodes in experiment. Materials and Methods. A series of experiments was performed on 80 guinea pigs, 30 Balb/c mice, 40 CBA/CaLac mice and 70 outbred mice of both genders. To study allergenicity various doses of preparation were administered subcutaneously, intramuscularly, intravenously, intradermally as a single injection or by a course. Allergizing properties of the radiopharmaceutical were investigated according to the “Guidelines on the assessment of allergizing properties of drugs”Results. Administration of Nanocolloid,99mTc‒Al2O3 radiopharmaceutical did not result in the intensification of anaphylaxis systemic reaction in the animals of the examined groups relative to the control. A single injection did not cause inflammatory reaction to Concanavalin A in the examined animals. When guinea pigs were immunized by the preparation, no delayed allergic reaction was revealed. Studying sensitizing effect of the preparation by 20 skin applications no redness or edema of the skin at the site of application was observed. Conclusion. Nanocolloid,99mTc‒Al2O3 radiopharmaceutical in the studied doses and under the selected experimental conditions does not possess allergizing properties.

AB - The aim of the investigation was to assess the allergizing properties of a new nanocolloidal preparation based on aluminum gamma-oxide labeled by technetium-99m for scintigraphic and intraoperative detection of sentinel lymphatic nodes in experiment. Materials and Methods. A series of experiments was performed on 80 guinea pigs, 30 Balb/c mice, 40 CBA/CaLac mice and 70 outbred mice of both genders. To study allergenicity various doses of preparation were administered subcutaneously, intramuscularly, intravenously, intradermally as a single injection or by a course. Allergizing properties of the radiopharmaceutical were investigated according to the “Guidelines on the assessment of allergizing properties of drugs”Results. Administration of Nanocolloid,99mTc‒Al2O3 radiopharmaceutical did not result in the intensification of anaphylaxis systemic reaction in the animals of the examined groups relative to the control. A single injection did not cause inflammatory reaction to Concanavalin A in the examined animals. When guinea pigs were immunized by the preparation, no delayed allergic reaction was revealed. Studying sensitizing effect of the preparation by 20 skin applications no redness or edema of the skin at the site of application was observed. Conclusion. Nanocolloid,99mTc‒Al2O3 radiopharmaceutical in the studied doses and under the selected experimental conditions does not possess allergizing properties.

KW - Allergizing properties

KW - Nanocolloid

KW - Radiopharmaceuticals

KW - Sentinel lymphatic node

UR - http://www.scopus.com/inward/record.url?scp=84952779493&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84952779493&partnerID=8YFLogxK

U2 - 10.17691/stm2015.7.4.09

DO - 10.17691/stm2015.7.4.09

M3 - Article

AN - SCOPUS:84952779493

VL - 7

SP - 72

EP - 76

JO - Sovremennye Tehnologii v Medicine

JF - Sovremennye Tehnologii v Medicine

SN - 2076-4243

IS - 4

ER -