Выдержка
The human body is constantly under attack from free radicals that occur as part of normal cell metabolism, and by exposure to environmental factors such as UV light, cigarette smoke, environmental pollutants and gamma radiation. The resulting "Reactive Oxygen Species" (ROS) circulate freely in the body with access to all organs and tissues, which can have serious repercussions throughout the body. The body possesses a number of mechanisms both to control the production of ROS and to cope with free radicals in order to limit or repair damage to tissues. Overproduction of ROS or insufficient defense mechanisms leads to a dangerous disbalance in the organism. Thereby several pathomechanisms implicated in over 100 human diseases, e.g., cardiovascular disease, cancer, diabetes mellitus, physiological disease, aging, etc., can be induced. Thus, a detailed investigation on the quantity of oxygen radicals, such as hydroxyl radicals (OH {filled circle}) in human serum blood, and its possible correlation with antioxidant therapy effects, is highly topical. The subject of this study was the influence of schizophrenia on the amount of OH {filled circle} in human serum blood. The radicals were detected by fluorimetry, using terephthalic acid as a chemical trap. For all experiments the serum blood of healthy peop le was used as a control group.
| Язык оригинала | Английский |
|---|---|
| Страницы (с-по) | 401-409 |
| Число страниц | 9 |
| Журнал | International Journal of Molecular Sciences |
| Том | 12 |
| Номер выпуска | 1 |
| DOI | |
| Состояние | Опубликовано - янв 2011 |
Отпечаток
ASJC Scopus subject areas
- Computer Science Applications
- Molecular Biology
- Catalysis
- Inorganic Chemistry
- Spectroscopy
- Organic Chemistry
- Physical and Theoretical Chemistry
- Medicine(all)
Цитировать
Study of OH center dot Radicals in Human Serum Blood of Healthy Individuals and Those with Pathological Schizophrenia. / Korotkova, Elena I.; Misini, Bashkim; Dorozhko, Elena V.; Bukkel, Mariya V.; Plotnikov, Evgeniy V.; Linert, Wolfgang.
В: International Journal of Molecular Sciences, Том 12, № 1, 01.2011, стр. 401-409.Результат исследований: Материалы для журнала › Статья
}
TY - JOUR
T1 - Study of OH center dot Radicals in Human Serum Blood of Healthy Individuals and Those with Pathological Schizophrenia
AU - Korotkova, Elena I.
AU - Misini, Bashkim
AU - Dorozhko, Elena V.
AU - Bukkel, Mariya V.
AU - Plotnikov, Evgeniy V.
AU - Linert, Wolfgang
PY - 2011/1
Y1 - 2011/1
N2 - The human body is constantly under attack from free radicals that occur as part of normal cell metabolism, and by exposure to environmental factors such as UV light, cigarette smoke, environmental pollutants and gamma radiation. The resulting "Reactive Oxygen Species" (ROS) circulate freely in the body with access to all organs and tissues, which can have serious repercussions throughout the body. The body possesses a number of mechanisms both to control the production of ROS and to cope with free radicals in order to limit or repair damage to tissues. Overproduction of ROS or insufficient defense mechanisms leads to a dangerous disbalance in the organism. Thereby several pathomechanisms implicated in over 100 human diseases, e.g., cardiovascular disease, cancer, diabetes mellitus, physiological disease, aging, etc., can be induced. Thus, a detailed investigation on the quantity of oxygen radicals, such as hydroxyl radicals (OH {filled circle}) in human serum blood, and its possible correlation with antioxidant therapy effects, is highly topical. The subject of this study was the influence of schizophrenia on the amount of OH {filled circle} in human serum blood. The radicals were detected by fluorimetry, using terephthalic acid as a chemical trap. For all experiments the serum blood of healthy peop le was used as a control group.
AB - The human body is constantly under attack from free radicals that occur as part of normal cell metabolism, and by exposure to environmental factors such as UV light, cigarette smoke, environmental pollutants and gamma radiation. The resulting "Reactive Oxygen Species" (ROS) circulate freely in the body with access to all organs and tissues, which can have serious repercussions throughout the body. The body possesses a number of mechanisms both to control the production of ROS and to cope with free radicals in order to limit or repair damage to tissues. Overproduction of ROS or insufficient defense mechanisms leads to a dangerous disbalance in the organism. Thereby several pathomechanisms implicated in over 100 human diseases, e.g., cardiovascular disease, cancer, diabetes mellitus, physiological disease, aging, etc., can be induced. Thus, a detailed investigation on the quantity of oxygen radicals, such as hydroxyl radicals (OH {filled circle}) in human serum blood, and its possible correlation with antioxidant therapy effects, is highly topical. The subject of this study was the influence of schizophrenia on the amount of OH {filled circle} in human serum blood. The radicals were detected by fluorimetry, using terephthalic acid as a chemical trap. For all experiments the serum blood of healthy peop le was used as a control group.
KW - Fluorimetry
KW - Human serum blood
KW - Hydroxyl radicals
KW - Schizophrenia
KW - Terephthalic acid
UR - http://www.scopus.com/inward/record.url?scp=79251607626&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79251607626&partnerID=8YFLogxK
U2 - 10.3390/ijms12010401
DO - 10.3390/ijms12010401
M3 - Article
C2 - 21339994
AN - SCOPUS:79251607626
VL - 12
SP - 401
EP - 409
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 1
ER -