Structurally diverse dendritic libraries: A highly efficient functionalization approach using click chemistry

Michael Malkoch, Kristin Schleicher, Eric Drockenmuller, Craig J. Hawker, Thomas P. Russell, Peng Wu, Valery V. Fokin

Результат исследования: Материалы для журналаСтатья

354 Цитирования (Scopus)

Аннотация

The high fidelity and efficiency of Click chemistry are exploited in the synthesis of a library of chain end functionalized dendritic macromolecules. In this example, the selectivity of the Cu-catalyzed [3 + 2π] cycloaddition reaction of azides with terminal acetylenes, coupled with mild reaction conditions, permits unprecedented functional group tolerance during the derivatization of dendrimeric and hyperbranched scaffolds. The resulting dendritic libraries are structurally diverse, encompassing a variety of backbones/surface functional groups, and are prepared in almost quantitative yields under very mild conditions. The robust and simple nature of this procedure, combined with its applicability to many aspects of polymer synthesis and materials chemistry, demonstrates an evolving synergy between advanced organic chemistry and functional materials.

Язык оригиналаАнглийский
Страницы (с... по...)3663-3678
Количество страниц16
ЖурналMacromolecules
Том38
Номер выпуска9
DOI
Статус публикацииОпубликовано - 3 мая 2005
Опубликовано для внешнего пользованияДа

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ASJC Scopus subject areas

  • Materials Chemistry

Цитировать

Malkoch, M., Schleicher, K., Drockenmuller, E., Hawker, C. J., Russell, T. P., Wu, P., & Fokin, V. V. (2005). Structurally diverse dendritic libraries: A highly efficient functionalization approach using click chemistry. Macromolecules, 38(9), 3663-3678. https://doi.org/10.1021/ma047657f