Stimulation of σ1 receptors alleviates reperfusion-induced myocardial stunning

L. N. Maslov, Yu B. Lishmanov

Результат исследований: Материалы для журналаСтатья

Выдержка

In vivo or in vitro administration of a σ1 receptor agonist d-SKF 10.047 (1 mg/kg intravenously or 10 mg/l in vitro) promoted an increase in the resistance of isolated perfused rat heart to ischemia/reperfusion injury. Both in vivo and in vitro stimulation of σ receptors prevents the development of reperfusion contracture and creatine kinase release and increases the developed pressure, double product, +dP/dt, and -dP/dt in the left ventricle. Activation of a receptors has no significant effect on the occurrence of reperfusion arrhythmias ex vivo. Stimulation of cardiac sigma receptors is proposed to prevent myocardial stunning.

Язык оригиналаАнглийский
Страницы (с-по)168-174
Число страниц7
ЖурналBiology Bulletin
Том31
Номер выпуска2
DOI
СостояниеОпубликовано - 1 мар 2004

Отпечаток

myocardial stunning
sigma Receptors
Myocardial Stunning
Creatine Kinase
Reperfusion
Rats
Chemical activation
receptors
Contracture
contracture
Reperfusion Injury
Heart Ventricles
Cardiac Arrhythmias
arrhythmia
creatine kinase
ischemia
agonists
Pressure
heart
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Цитировать

Stimulation of σ1 receptors alleviates reperfusion-induced myocardial stunning. / Maslov, L. N.; Lishmanov, Yu B.

В: Biology Bulletin, Том 31, № 2, 01.03.2004, стр. 168-174.

Результат исследований: Материалы для журналаСтатья

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