Sol-gel synthesis of mesoporous silicas containing albumin and guanidine polymers and its application to the bilirubin adsorption

A. S. Timin, E. V. Rumyantsev

Результат исследования: Материалы для журналаСтатья

9 Цитирования (Scopus)

Аннотация

The organic-inorganic composite materials based on mesoporous silica were synthesized using sol-gel method. The surface area of silicas was modified by bovine serum albumin (BSA) and guanidine polymers: polyacrylate guanidine (PAG) and polymethacrylate guanidine. The mesoporous silicas were characterized by nitrogen adsorption-desorption analysis, Fourier transform infrared spectroscopy, transmission electron microscopy. The obtained materials were used as adsorbents for selective bilirubin removal. It was shown that the structural properties and surface area of modified materials depend on the nature of polymers. Incorporation of polymers in silica gel matrix during sol-gel process leads to the formation of mesoporous structure with high pore diameter and a BET surface area equals to 346 m2/g for SiO2/BSA and 160 m2/g for SiO2/PAG. Analysis of adsorption isotherms showed that modification of silica by BSA and guanidine polymers increases its adsorption ability to bilirubin molecules. According to Langmuir model, the maximum bilirubin adsorption capacity was 1.18 mg/g.

Язык оригиналаАнглийский
Страницы (с... по...)297-303
Количество страниц7
ЖурналJournal of Sol-Gel Science and Technology
Том67
Номер выпуска2
DOI
Статус публикацииОпубликовано - авг 2013
Опубликовано для внешнего пользованияДа

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ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics
  • Biomaterials
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Materials Chemistry

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