Searching for new synthetic diuretics

I. V. Smirnov, T. O. Murashko, A. A. Ivanov, A. O. Nemtsev, A. A. Bondarev, V. V. Udut

Результат исследования: Материалы для журналаСтатья


This study was aimed at estimation of the diuretic and saluretic activity of 4-nitrophenyl-O-β-D-glucopyranoside and its aglicon 4-nitrophenol in rats. Test animals daily received 4-nitrophenyl-O-β-D-glucopyranoside (group 1) and 4-nitrophenol (group 2) intragastrically in 2 mL of distilled water in a dose of 18 μ mol/kg from 1st to 7th day and 54 |jmol/kg from 8th to 14th days. During the experiment, the most pronounced diuretic activity was observed for 4-nitrophe-nyl-O-β-D-glucopyranoside in a dose of 54 μmol/kg, which increased the diuresis in rats 2.5 times as compared to the control value.

Язык оригиналаАнглийский
Страницы (с... по...)3-5
Количество страниц3
ЖурналEksperimental'naya i Klinicheskaya Farmakologiya
Номер выпуска12
Статус публикацииОпубликовано - 1 янв 2015


ASJC Scopus subject areas

  • Toxicology
  • Pharmacology


Smirnov, I. V., Murashko, T. O., Ivanov, A. A., Nemtsev, A. O., Bondarev, A. A., & Udut, V. V. (2015). Searching for new synthetic diuretics. Eksperimental'naya i Klinicheskaya Farmakologiya, 78(12), 3-5.