Role of endothelial nitric oxide in cerebrovascular regulation

Dmitriy N. Atochin, Paul L. Huang

Результат исследований: Материалы для журналаСтатья

16 Цитирования (Scopus)

Аннотация

Endothelial nitric oxide (NO) plays important roles in the vascular system. Animal models that show vascular dysfunction demonstrate the protective role of endothelial NO dependent pathways. This review focuses on the role of endothelial NO in the regulation of cerebral blood flow and vascular tone. We will discuss the importance of NO in cerebrovascular function using animal models with altered endothelial NO production under normal, ischemic and reperfusion conditions, as well as in hyperoxia. Pharmacological and genetic manipulations of the endothelial NO system demonstrate the essential roles of endothelial NO synthase in maintenance of vascular tone and cerebral perfusion under normal and pathological conditions.

Язык оригиналаАнглийский
Страницы (с-по)1334-1342
Число страниц9
ЖурналCurrent Pharmaceutical Biotechnology
Том12
Номер выпуска9
СостояниеОпубликовано - сен 2011
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Biotechnology

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