Role of endogenous opioid receptor agonists in regulation of heart resistence to the arrhythmogenic action of short-term ischemia and reperfusion

L. N. Maslov, Yu B. Lishmanov, N. V. Naryzhnaya, E. V. Budankova, D. L. Stakheev, N. V. Solenkova, E. I. Barzakh, P. R. Oeltgen, G. J. Gross

Результат исследований: Материалы для журналаСтатья

2 Цитирования (Scopus)

Выдержка

Preliminary selective block of μ-, δ1-, δ2-, and κ-opioid receptors had no effect on the incidence of ventricular arrhythmias during 10-min coronary occlusion-reperfusion in ketamine-narcotized rats. Repetitive short-term immobilization of rats for 2 weeks improved heart resistance to the arrhythmogenic action of coronary occlusion and reperfusion. Selective μ-opioid receptor antagonist CTAP completely abolished, while selective δ- and κ-opioid receptor antagonists did not modulate the antiarrhythmic effect of adaptation. Probably, endogenous agonists of μ-opioid receptors play an important role in the adaptive improvement of heart resistance to arrhythmogenic factors, but are insignificant for the modulation of heart resistance to the arrhythmogenic action of short-term local ischemia-reperfusion in non-adapted animals.

Язык оригиналаАнглийский
Страницы (с-по)172-175
Число страниц4
ЖурналBulletin of Experimental Biology and Medicine
Том139
Номер выпуска2
DOI
СостояниеОпубликовано - 1 фев 2005

Отпечаток

Opioid Receptors
Reperfusion
Myocardial Reperfusion
Narcotic Antagonists
Ischemia
Coronary Occlusion
Rats
Ketamine
Immobilization
Cardiac Arrhythmias
Animals
Modulation
Incidence

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Цитировать

Role of endogenous opioid receptor agonists in regulation of heart resistence to the arrhythmogenic action of short-term ischemia and reperfusion. / Maslov, L. N.; Lishmanov, Yu B.; Naryzhnaya, N. V.; Budankova, E. V.; Stakheev, D. L.; Solenkova, N. V.; Barzakh, E. I.; Oeltgen, P. R.; Gross, G. J.

В: Bulletin of Experimental Biology and Medicine, Том 139, № 2, 01.02.2005, стр. 172-175.

Результат исследований: Материалы для журналаСтатья

Maslov, L. N. ; Lishmanov, Yu B. ; Naryzhnaya, N. V. ; Budankova, E. V. ; Stakheev, D. L. ; Solenkova, N. V. ; Barzakh, E. I. ; Oeltgen, P. R. ; Gross, G. J. / Role of endogenous opioid receptor agonists in regulation of heart resistence to the arrhythmogenic action of short-term ischemia and reperfusion. В: Bulletin of Experimental Biology and Medicine. 2005 ; Том 139, № 2. стр. 172-175.
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AU - Lishmanov, Yu B.

AU - Naryzhnaya, N. V.

AU - Budankova, E. V.

AU - Stakheev, D. L.

AU - Solenkova, N. V.

AU - Barzakh, E. I.

AU - Oeltgen, P. R.

AU - Gross, G. J.

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KW - Arrhythmia

KW - Heart

KW - Ischemia

KW - Opioid receptors

KW - Reperfusion

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