Role of Endogenous Agonists of Opioid Receptors in the Regulation of Heart Resistance to Postischemic Reperfusion Injury

A. S. Gorbunov, O. E. Vaizova, M. V. Belousov, S. V. Pozdnyakova, E. A. Nesterov, P. G. Madonov

Результат исследований: Материалы для журналаСтатья

1 Цитирования (Scopus)

Аннотация

Intravenous injection of nonselective antagonists of opioid receptors (OR) naltrexone (5 mg/kg) and naloxone methiodide (5 mg/kg), selective δ1-OR antagonist BNTX (0.7 mg/kg), selective δ2-OR blocker naltriben (0.3 mg/kg), selective κ-OR antagonist norbinaltorphimine (2 mg/kg), and selective blocker of ORL1 opioid receptors JTC-801 (0.1 mg/kg) produced no effect on reperfusion injury to the heart in rats narcotized with α-chloralose. In contrast, selective μ-OR antagonist CTAP (1 mg/kg) limited the infarct size, although this effect was not observed at a lower CTAP concentration of 0.1 mg/kg. Probably, the myocardial infarct size-limiting effect of CTAP was associated with activation of the non-opioid receptors. It was hypothesized that endogenous OR agonists did not affect heart resistance to reperfusion injury in unadapted rats.

Язык оригиналаАнглийский
Страницы (с-по)1-3
Число страниц3
ЖурналBulletin of Experimental Biology and Medicine
Том164
Номер выпуска1
DOI
СостояниеПринято/в печати - 9 ноя 2017

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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