Role of ATP-Sensitive K+ Channels in Myocardial Infarct Size-Limiting Effect of Chronic Continuous Normobaric Hypoxia

Y. B. Lishmanov, N. V. Naryzhnaya, S. Y. Tsibul’nikov, H. Wang, Leonid N. Maslov

Результат исследований: Материалы для журналаСтатья

3 Цитирования (Scopus)

Аннотация

The role of KATP channels in myocardial infarct size-limiting effect of chronic continuous normobaric hypoxia was examined in a rat model based on a 20-min coronary occlusion and subsequent 3-h reperfusion. Rats were adapted to normobaric hypoxia (12% O2) for 21 days. This hypoxia produced a pronounced infarct size-limiting effect, which had been prevented by 0.3 mg/kg glibenclamide, a non-selective inhibitor of entire pool of KATP channels, or 5 mg/kg 5-hydroxydecanoate, an inhibitor of mitochondrial KATP channels. The study highlighted the important role of mitochondrial KATP channels in myocardial infarct size-limiting effect of chronic normobaric hypoxia.

Язык оригиналаАнглийский
Страницы (с-по)1-3
Число страниц3
ЖурналBulletin of Experimental Biology and Medicine
Том163
Номер выпуска1
DOI
СостояниеПринято/в печати - 2 июн 2017

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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