Ribonuclease from Bacillus thuringiensis var. subtoxicus: Gene structure and regulation of biosynthesis

A. A. Shulga, L. V. Znamenskaya, O. V. Morozova, I. B. Leshchinskaya, M. P. Kirpichnikov

Результат исследований: Материалы для журналаОбзорная статьярецензирование

2 Цитирования (Scopus)

Аннотация

The gene for extracellular guanyl-specific ribonuclease of Bacillus thuringiensis var. subtoxicus (RNase Bth), a close homologue of the B. intermedius RNase (binase), was completely sequenced. Analysis of nucleotide sequences in the regions adjoining RNase genes revealed an identical organization of the chromosomal loci of RNase Bth and binase. Growth characteristics of the Bacillus thuringiensis var. subtoxicus strain and its synthesis of RNase were studied. It was shown that the exogenous inorganic phosphate inhibits the biosynthesis of RNase. At the same time, actinomycin D in low doses stimulates the enzyme synthesis. Comparative analysis of the influence of inorganic phosphate and actinomycin D on the biosynthesis of RNase Bth and binase suggests a possibility of coincidence of regulatory pathways of synthesis of these enzymes.

Язык оригиналаАнглийский
Страницы (с-по)603-609
Число страниц7
ЖурналRussian Journal of Bioorganic Chemistry
Том26
Номер выпуска9
СостояниеОпубликовано - сен 2000
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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