Regioselective synthesis of either 1H- or 2H-1,2,3-triazoles via Michael addition to α,β-unsaturated ketones

Sen Wai Kwok, Jason E. Hein, Valery V. Fokin, K. Barry Sharpless

Результат исследований: Материалы для журналаСтатья

11 Цитирования (Scopus)

Выдержка

The Michael reaction of NH-1,2,3-triazole (1) with α,β-unsaturated ketones was studied. 1H-1,2,3-triazolyl-ketones were selectively generated when 1 was combined neat with a variety of enones. The use of aprotic solvents with catalytic base gave the corresponding 2H-regioisomers. Together, these two protocols provide direct access to either the N1- or N2-substituted 1,3-triazolyl ketone regioisomers.

Язык оригиналаАнглийский
Страницы (с-по)1141-1154
Число страниц14
ЖурналHeterocycles
Том76
Номер выпуска2
DOI
СостояниеОпубликовано - 1 ноя 2008
Опубликовано для внешнего пользованияДа

Отпечаток

Triazoles
Ketones

ASJC Scopus subject areas

  • Analytical Chemistry
  • Organic Chemistry
  • Pharmacology

Цитировать

Regioselective synthesis of either 1H- or 2H-1,2,3-triazoles via Michael addition to α,β-unsaturated ketones. / Kwok, Sen Wai; Hein, Jason E.; Fokin, Valery V.; Sharpless, K. Barry.

В: Heterocycles, Том 76, № 2, 01.11.2008, стр. 1141-1154.

Результат исследований: Материалы для журналаСтатья

Kwok, Sen Wai ; Hein, Jason E. ; Fokin, Valery V. ; Sharpless, K. Barry. / Regioselective synthesis of either 1H- or 2H-1,2,3-triazoles via Michael addition to α,β-unsaturated ketones. В: Heterocycles. 2008 ; Том 76, № 2. стр. 1141-1154.
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T1 - Regioselective synthesis of either 1H- or 2H-1,2,3-triazoles via Michael addition to α,β-unsaturated ketones

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AU - Sharpless, K. Barry

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KW - N1 - to N2- Isomerization

KW - NH-1,2,3-triazole

KW - Solvent-Free Reaction

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