Regioselective synthesis of either 1H- or 2H-1,2,3-triazoles via Michael addition to α,β-unsaturated ketones

Sen Wai Kwok, Jason E. Hein, Valery V. Fokin, K. Barry Sharpless

Результат исследований: Материалы для журналаСтатья

12 Цитирования (Scopus)

Аннотация

The Michael reaction of NH-1,2,3-triazole (1) with α,β-unsaturated ketones was studied. 1H-1,2,3-triazolyl-ketones were selectively generated when 1 was combined neat with a variety of enones. The use of aprotic solvents with catalytic base gave the corresponding 2H-regioisomers. Together, these two protocols provide direct access to either the N1- or N2-substituted 1,3-triazolyl ketone regioisomers.

Язык оригиналаАнглийский
Страницы (с-по)1141-1154
Число страниц14
ЖурналHeterocycles
Том76
Номер выпуска2
DOI
СостояниеОпубликовано - 1 ноя 2008
Опубликовано для внешнего пользованияДа

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Organic Chemistry
  • Pharmacology

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