Regionally Influenced Content of Selenium and Its Capacity under Postoperative Myocardial Remodeling in Cardiac Surgery Patients

A. I. Stelmashenko, S. A. Beliaeva, G. B. Slepchenko

Результат исследований: Материалы для журналарецензирование

Аннотация

Selenium (Se) is an essential micronutrient in living organisms; however, some aspects of its metabolism and function remain unknown. Se deficiency causes significant disturbances in the cardiovascular system along with left ventricular (LV) fibrosis. Simultaneously, an understanding of pathways that influence Se role in heart failure progression is insufficient. Therefore, clinical studies are needed to characterize Se importance in developing post-infarct LV dysfunction and postoperative remodeling. In the Tomsk region, the level of Se in healthy people and the myocardium of patients with ischemic cardiomyopathy was close to normal. Quantitative chemical analysis of Se content in hair samples and LV myocardium was based on stripping voltammetry to determine mass concentrations of the micro-element. Nevertheless, a significant number of cardiac surgery patients showed negative dynamics of postoperative LV myocardium remodeling with the development of heart failure. We obtained preliminary results of a direct correlation between favorable outcomes of postoperative adaptive myocardial remodeling (AR) and maladaptive myocardial remodeling (MALR) with different Se concentrations in the myocardium. Simultaneously, about 84% of patients showed abnormal postoperative LV MALR in high Se in the myocardium. Further in-depth studies are required to translate novel data from the laboratory bench to the clinics.

Язык оригиналаАнглийский
Номер статьи012027
ЖурналIOP Conference Series: Earth and Environmental Science
Том670
Номер выпуска1
DOI
СостояниеОпубликовано - 26 фев 2021
Событие2020 International Scientific and Practical Forum on Natural Resources, the Environment, and Sustainability, NRES 2020 - Barnaul, Российская Федерация
Продолжительность: 22 окт 202023 окт 2020

ASJC Scopus subject areas

  • Environmental Science(all)
  • Earth and Planetary Sciences(all)

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