Receptor specificity of the antiarrhythmic effect produced by opioid peptides dalargin and DADLE during myocardial reperfusion

N. V. Naryzhnaya, L. N. Maslov, Yu B. Lishmanov, G. J. Gross

Учебно-научный центр "Исследовательский ядерный реактор"

Результат исследований: Материалы для журнала › Статья

Выдержка

Nonselective agonists of μ- and δ-opioid receptors dalargin (D-Ala²,Leu⁵,Arg⁶-enkephalin) and DADLE (D-Ala²,D-Leu⁵-enkephalin) administered immediately before coronary reperfusion in a dose of 0.1 mg/kg prevented the development of ventricular arrhythmias. Blockade of μ-opioid receptors abolished the antiarrhythmic effect of these peptides. Hence, antiarrhythmic activity of dalargin and DADLE is primarily associated with activation of μ-opioid receptors.

Язык оригинала	Английский
Страницы (с-по)	336-338
Число страниц	3
Журнал	Bulletin of Experimental Biology and Medicine
Том	133
Номер выпуска	4
DOI	https://doi.org/10.1023/A:1016229517353
Состояние	Опубликовано - 1 апр 2002

Отпечаток

Myocardial Reperfusion

Opioid Peptides

Enkephalins

Opioid Receptors

Chemical activation

Cardiac Arrhythmias

Peptides

Ala(2)-enkephalinamide-met

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Цитировать

Naryzhnaya, N. V., Maslov, L. N., Lishmanov, Y. B., & Gross, G. J. (2002). Receptor specificity of the antiarrhythmic effect produced by opioid peptides dalargin and DADLE during myocardial reperfusion. Bulletin of Experimental Biology and Medicine, 133(4), 336-338. https://doi.org/10.1023/A:1016229517353

Receptor specificity of the antiarrhythmic effect produced by opioid peptides dalargin and DADLE during myocardial reperfusion. / Naryzhnaya, N. V.; Maslov, L. N.; Lishmanov, Yu B.; Gross, G. J.

В: Bulletin of Experimental Biology and Medicine, Том 133, № 4, 01.04.2002, стр. 336-338.

Результат исследований: Материалы для журнала › Статья

Naryzhnaya, NV, Maslov, LN, Lishmanov, YB & Gross, GJ 2002, 'Receptor specificity of the antiarrhythmic effect produced by opioid peptides dalargin and DADLE during myocardial reperfusion', Bulletin of Experimental Biology and Medicine, том. 133, № 4, стр. 336-338. https://doi.org/10.1023/A:1016229517353

Naryzhnaya NV, Maslov LN, Lishmanov YB, Gross GJ. Receptor specificity of the antiarrhythmic effect produced by opioid peptides dalargin and DADLE during myocardial reperfusion. Bulletin of Experimental Biology and Medicine. 2002 Апр. 1;133(4):336-338. https://doi.org/10.1023/A:1016229517353

Naryzhnaya, N. V. ; Maslov, L. N. ; Lishmanov, Yu B. ; Gross, G. J. / Receptor specificity of the antiarrhythmic effect produced by opioid peptides dalargin and DADLE during myocardial reperfusion. В: Bulletin of Experimental Biology and Medicine. 2002 ; Том 133, № 4. стр. 336-338.

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abstract = "Nonselective agonists of μ- and δ-opioid receptors dalargin (D-Ala2,Leu5,Arg6-enkephalin) and DADLE (D-Ala2,D-Leu5-enkephalin) administered immediately before coronary reperfusion in a dose of 0.1 mg/kg prevented the development of ventricular arrhythmias. Blockade of μ-opioid receptors abolished the antiarrhythmic effect of these peptides. Hence, antiarrhythmic activity of dalargin and DADLE is primarily associated with activation of μ-opioid receptors.",

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Доступ к документам

10.1023/A:1016229517353