Receptor specificity of the antiarrhythmic effect produced by opioid peptides dalargin and DADLE during myocardial reperfusion

N. V. Naryzhnaya, L. N. Maslov, Yu B. Lishmanov, G. J. Gross

Результат исследований: Материалы для журналаСтатья

2 Цитирования (Scopus)

Выдержка

Nonselective agonists of μ- and δ-opioid receptors dalargin (D-Ala2,Leu5,Arg6-enkephalin) and DADLE (D-Ala2,D-Leu5-enkephalin) administered immediately before coronary reperfusion in a dose of 0.1 mg/kg prevented the development of ventricular arrhythmias. Blockade of μ-opioid receptors abolished the antiarrhythmic effect of these peptides. Hence, antiarrhythmic activity of dalargin and DADLE is primarily associated with activation of μ-opioid receptors.

Язык оригиналаАнглийский
Страницы (с-по)336-338
Число страниц3
ЖурналBulletin of Experimental Biology and Medicine
Том133
Номер выпуска4
DOI
СостояниеОпубликовано - 1 апр 2002

Отпечаток

Myocardial Reperfusion
Opioid Peptides
Enkephalins
Opioid Receptors
Chemical activation
Cardiac Arrhythmias
Peptides
Ala(2)-enkephalinamide-met

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Цитировать

Receptor specificity of the antiarrhythmic effect produced by opioid peptides dalargin and DADLE during myocardial reperfusion. / Naryzhnaya, N. V.; Maslov, L. N.; Lishmanov, Yu B.; Gross, G. J.

В: Bulletin of Experimental Biology and Medicine, Том 133, № 4, 01.04.2002, стр. 336-338.

Результат исследований: Материалы для журналаСтатья

@article{fc695503c0194e97aee7af20c3d7e63b,
title = "Receptor specificity of the antiarrhythmic effect produced by opioid peptides dalargin and DADLE during myocardial reperfusion",
abstract = "Nonselective agonists of μ- and δ-opioid receptors dalargin (D-Ala2,Leu5,Arg6-enkephalin) and DADLE (D-Ala2,D-Leu5-enkephalin) administered immediately before coronary reperfusion in a dose of 0.1 mg/kg prevented the development of ventricular arrhythmias. Blockade of μ-opioid receptors abolished the antiarrhythmic effect of these peptides. Hence, antiarrhythmic activity of dalargin and DADLE is primarily associated with activation of μ-opioid receptors.",
keywords = "DADLE, Dalargin, Opioid receptors, Reperfusion arrhythmias",
author = "Naryzhnaya, {N. V.} and Maslov, {L. N.} and Lishmanov, {Yu B.} and Gross, {G. J.}",
year = "2002",
month = "4",
day = "1",
doi = "10.1023/A:1016229517353",
language = "English",
volume = "133",
pages = "336--338",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Receptor specificity of the antiarrhythmic effect produced by opioid peptides dalargin and DADLE during myocardial reperfusion

AU - Naryzhnaya, N. V.

AU - Maslov, L. N.

AU - Lishmanov, Yu B.

AU - Gross, G. J.

PY - 2002/4/1

Y1 - 2002/4/1

N2 - Nonselective agonists of μ- and δ-opioid receptors dalargin (D-Ala2,Leu5,Arg6-enkephalin) and DADLE (D-Ala2,D-Leu5-enkephalin) administered immediately before coronary reperfusion in a dose of 0.1 mg/kg prevented the development of ventricular arrhythmias. Blockade of μ-opioid receptors abolished the antiarrhythmic effect of these peptides. Hence, antiarrhythmic activity of dalargin and DADLE is primarily associated with activation of μ-opioid receptors.

AB - Nonselective agonists of μ- and δ-opioid receptors dalargin (D-Ala2,Leu5,Arg6-enkephalin) and DADLE (D-Ala2,D-Leu5-enkephalin) administered immediately before coronary reperfusion in a dose of 0.1 mg/kg prevented the development of ventricular arrhythmias. Blockade of μ-opioid receptors abolished the antiarrhythmic effect of these peptides. Hence, antiarrhythmic activity of dalargin and DADLE is primarily associated with activation of μ-opioid receptors.

KW - DADLE

KW - Dalargin

KW - Opioid receptors

KW - Reperfusion arrhythmias

UR - http://www.scopus.com/inward/record.url?scp=0036554835&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036554835&partnerID=8YFLogxK

U2 - 10.1023/A:1016229517353

DO - 10.1023/A:1016229517353

M3 - Article

C2 - 12124638

AN - SCOPUS:0036554835

VL - 133

SP - 336

EP - 338

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 4

ER -