Аннотация
Nonselective agonists of μ- and δ-opioid receptors dalargin (D-Ala2,Leu5,Arg6-enkephalin) and DADLE (D-Ala2,D-Leu5-enkephalin) administered immediately before coronary reperfusion in a dose of 0.1 mg/kg prevented the development of ventricular arrhythmias. Blockade of μ-opioid receptors abolished the antiarrhythmic effect of these peptides. Hence, antiarrhythmic activity of dalargin and DADLE is primarily associated with activation of μ-opioid receptors.
Язык оригинала | Английский |
---|---|
Страницы (с-по) | 336-338 |
Число страниц | 3 |
Журнал | Bulletin of Experimental Biology and Medicine |
Том | 133 |
Номер выпуска | 4 |
DOI | |
Состояние | Опубликовано - 1 апр 2002 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)