Receptor specificity of the antiarrhythmic effect produced by opioid peptides dalargin and DADLE during myocardial reperfusion

N. V. Naryzhnaya, L. N. Maslov, Yu B. Lishmanov, G. J. Gross

Учебно-научный центр "Исследовательский ядерный реактор"

Результат исследований: Материалы для журнала › Статья › рецензирование

Аннотация

Nonselective agonists of μ- and δ-opioid receptors dalargin (D-Ala²,Leu⁵,Arg⁶-enkephalin) and DADLE (D-Ala²,D-Leu⁵-enkephalin) administered immediately before coronary reperfusion in a dose of 0.1 mg/kg prevented the development of ventricular arrhythmias. Blockade of μ-opioid receptors abolished the antiarrhythmic effect of these peptides. Hence, antiarrhythmic activity of dalargin and DADLE is primarily associated with activation of μ-opioid receptors.

Язык оригинала	Английский
Страницы (с-по)	336-338
Число страниц	3
Журнал	Bulletin of Experimental Biology and Medicine
Том	133
Номер выпуска	4
DOI	https://doi.org/10.1023/A:1016229517353
Состояние	Опубликовано - 1 апр 2002

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Доступ к документу

10.1023/A:1016229517353

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Receptor specificity of the antiarrhythmic effect produced by opioid peptides dalargin and DADLE during myocardial reperfusion. / Naryzhnaya, N. V.; Maslov, L. N.; Lishmanov, Yu B.; Gross, G. J.

В: Bulletin of Experimental Biology and Medicine, Том 133, № 4, 01.04.2002, стр. 336-338.

Результат исследований: Материалы для журнала › Статья › рецензирование

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abstract = "Nonselective agonists of μ- and δ-opioid receptors dalargin (D-Ala2,Leu5,Arg6-enkephalin) and DADLE (D-Ala2,D-Leu5-enkephalin) administered immediately before coronary reperfusion in a dose of 0.1 mg/kg prevented the development of ventricular arrhythmias. Blockade of μ-opioid receptors abolished the antiarrhythmic effect of these peptides. Hence, antiarrhythmic activity of dalargin and DADLE is primarily associated with activation of μ-opioid receptors.",

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AU - Naryzhnaya, N. V.

AU - Maslov, L. N.

AU - Lishmanov, Yu B.

AU - Gross, G. J.

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AB - Nonselective agonists of μ- and δ-opioid receptors dalargin (D-Ala2,Leu5,Arg6-enkephalin) and DADLE (D-Ala2,D-Leu5-enkephalin) administered immediately before coronary reperfusion in a dose of 0.1 mg/kg prevented the development of ventricular arrhythmias. Blockade of μ-opioid receptors abolished the antiarrhythmic effect of these peptides. Hence, antiarrhythmic activity of dalargin and DADLE is primarily associated with activation of μ-opioid receptors.

KW - DADLE

KW - Dalargin

KW - Opioid receptors

KW - Reperfusion arrhythmias

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