@inproceedings{deb300db57c24210aff1f6b84e1949bd,
title = "Radiopharmaceuticals for SPECT cancer detection",
abstract = "The purpose of the study was to assess the efficacy of single photon emission computed tomography (SPECT) with 199Tl and 99mTc-MIBI in the detection of breast, laryngeal and hypopharyngeal cancers. A total of 220 patients were included into the study: 120 patients with breast lesions (100 patients with breast cancer and 20 patients with benign breast tumors) and 100 patients with laryngeal/hypopharyngeal diseases (80 patients with laryngeal/hypopharyngeal cancer and 20 patients with benign laryngeal/hypopharyngeal lesions). No abnormal 199Tl uptake was seen in all patients with benign breast and laryngeal lesions, indicating a 100% specificity of 199Tl SPECT. In the breast cancer patients, the increased 199Tl uptake in the breast was visualized in 94.8% patients, 99mTc-MIBI - in 93.4% patients. The increased 199Tl uptake in axillary lymph nodes was detected in 60% patients, and 99mTc-MIBI - in 93.1% patients. In patients with laryngeal/hypopharyngeal cancer, the sensitivity of SPECT with 199Tl and 99mTc-MIBI was 95%. The 199Tl SPECT sensitivity in identification of regional lymph node metastases in the patients with laryngeal/hypopharyngeal cancer was 75% and the 99mTc-MIBI SPECT sensitivity was 17%. The data obtained showed that SPECT with 199Tl and 99mTc-MIBI can be used as one of the additional imaging methods in detection of tumors.",
author = "Chernov, {V. I.} and Medvedeva, {A. A.} and Zelchan, {R. V.} and Sinilkin, {I. G.} and Stasyuk, {E. S.} and Larionova, {L. A.} and Slonimskaya, {E. M.} and Choynzonov, {E. L.}",
year = "2016",
month = aug,
day = "2",
doi = "10.1063/1.4960230",
language = "English",
series = "AIP Conference Proceedings",
publisher = "American Institute of Physics Inc.",
editor = "Sharkeev, {Yurii P.} and Naimark, {Oleg B.} and Gutmanas, {Elazar Y.}",
booktitle = "Physics of Cancer",
note = "International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016, PC 2016 ; Conference date: 22-03-2016 Through 25-03-2016",
}