Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion

S. Yu Tsibulnikov, L. N. Maslov, A. V. Mukhomedzyanov, A. V. Krylatov, M. R. Tsibulnikova, Yu B. Lishmanov

Результат исследований: Материалы для журналаСтатья

4 Цитирования (Scopus)

Аннотация

We studied the ability of the agonist of κ1-opioid receptors U-50,488 in doses of 0.1 and 1 mg/kg to simulate ischemic pre- and postconditioning of the heart and κ-opioid receptors ICI 199,441 in a dose of 0.1 mg/kg to simulate the antiarrhythmic effect of heart preconditioning. The duration of ischemia was 10 or 45 min and the duration of reperfusion was 10 min or 2 h. Administration of 1 mg/kg U-50,488 both before ischemia and 5 min before reperfusion produced a pronounced antiarrhythmic effect. U-50,488 injected 5 min before reperfusion 2-fold reduced the ratio of infarction to risk area. Administration of ICI 199,441 in a dose of 0.1 mg/kg 15 min before ischemia produced a potent antiarrhythmic effect. Antiarrhythmic effect of κ-opioid receptor agonists depended on activation of κ-opioid receptors.

Язык оригиналаАнглийский
Страницы (с-по)718-721
Число страниц4
ЖурналBulletin of Experimental Biology and Medicine
Том159
Номер выпуска6
DOI
СостояниеОпубликовано - 1 окт 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Подробные сведения о темах исследования «Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion». Вместе они формируют уникальный семантический отпечаток (fingerprint).

  • Цитировать