Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists

Leonid N. Maslov, Igor Khaliulin, Peter R. Oeltgen, Natalia V. Naryzhnaya, Jian Ming Pei, Stephen A. Brown, Yury B. Lishmanov, James M. Downey

Результат исследований: Материалы для журналаОбзорная статья

10 Цитирования (Scopus)

Выдержка

It has now been demonstrated that the μ, δ1, δ2, and κ1 opioid receptor (OR) agonists represent the most promising group of opioids for the creation of drugs enhancing cardiac tolerance to the detrimental effects of ischemia/reperfusion (I/R). Opioids are able to prevent necrosis and apoptosis of cardiomyocytes during I/R and improve cardiac contractility in the reperfusion period. The OR agonists exert an infarct-reducing effect with prophylactic administration and prevent reperfusion-induced cardiomyocyte death when ischemic injury of heart has already occurred; that is, opioids can mimic preconditioning and postconditioning phenomena. Furthermore, opioids are also effective in preventing ischemia-induced arrhythmias.

Язык оригиналаАнглийский
Страницы (с-по)871-923
Число страниц53
ЖурналMedicinal Research Reviews
Том36
Номер выпуска5
DOI
СостояниеОпубликовано - 1 сен 2016

Отпечаток

Anti-Arrhythmia Agents
Opioid Receptors
Opioid Analgesics
Reperfusion
Ischemia
Cardiac Myocytes
Heart Injuries
Cardiac Arrhythmias
Necrosis
Apoptosis
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

Цитировать

Maslov, L. N., Khaliulin, I., Oeltgen, P. R., Naryzhnaya, N. V., Pei, J. M., Brown, S. A., ... Downey, J. M. (2016). Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists. Medicinal Research Reviews, 36(5), 871-923. https://doi.org/10.1002/med.21395

Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists. / Maslov, Leonid N.; Khaliulin, Igor; Oeltgen, Peter R.; Naryzhnaya, Natalia V.; Pei, Jian Ming; Brown, Stephen A.; Lishmanov, Yury B.; Downey, James M.

В: Medicinal Research Reviews, Том 36, № 5, 01.09.2016, стр. 871-923.

Результат исследований: Материалы для журналаОбзорная статья

Maslov, LN, Khaliulin, I, Oeltgen, PR, Naryzhnaya, NV, Pei, JM, Brown, SA, Lishmanov, YB & Downey, JM 2016, 'Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists', Medicinal Research Reviews, том. 36, № 5, стр. 871-923. https://doi.org/10.1002/med.21395
Maslov LN, Khaliulin I, Oeltgen PR, Naryzhnaya NV, Pei JM, Brown SA и соавт. Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists. Medicinal Research Reviews. 2016 Сент. 1;36(5):871-923. https://doi.org/10.1002/med.21395
Maslov, Leonid N. ; Khaliulin, Igor ; Oeltgen, Peter R. ; Naryzhnaya, Natalia V. ; Pei, Jian Ming ; Brown, Stephen A. ; Lishmanov, Yury B. ; Downey, James M. / Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists. В: Medicinal Research Reviews. 2016 ; Том 36, № 5. стр. 871-923.
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