TY - JOUR
T1 - Preparation of [76Br] 5-bromo-2-thiouracil, a positron-emitting melanoma localizing agent
AU - Tolmachev, V.
AU - Orlova, A.
AU - Sundin, A.
N1 - Funding Information:
The authors would like to thank the staff at the Uppsala University PET Centre for their assistance with the radiobromine production. We also gratefully acknowledge The Svedberg Laboratory for allowing us to use their facilities. This work was supported by the Swedish Cancer Foundation.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2002
Y1 - 2002
N2 - Derivatives of 2-thiouracil are known to incorporate into the growing melanin pigment of melanomas as false melanin precursors. Animal and pilot patient studies have demonstrated, that radioiodinated 5-iodo-2-thiouracil is a promising agent for visualization of melanotic melanomas. In this study, 2-bromo-2-thiouracil was labeled using the positron-emitting isotope 76Br (T1/2 = 16.2 h), which potentially enables to use such advantages of PET as superior spatial resolution and possibility to quantify radioactivity concentration in vivo. The use of Chloramine-T as oxidant provided a labeling efficiency of about 70%.
AB - Derivatives of 2-thiouracil are known to incorporate into the growing melanin pigment of melanomas as false melanin precursors. Animal and pilot patient studies have demonstrated, that radioiodinated 5-iodo-2-thiouracil is a promising agent for visualization of melanotic melanomas. In this study, 2-bromo-2-thiouracil was labeled using the positron-emitting isotope 76Br (T1/2 = 16.2 h), which potentially enables to use such advantages of PET as superior spatial resolution and possibility to quantify radioactivity concentration in vivo. The use of Chloramine-T as oxidant provided a labeling efficiency of about 70%.
UR - http://www.scopus.com/inward/record.url?scp=0036206821&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036206821&partnerID=8YFLogxK
U2 - 10.1023/A:1014873923439
DO - 10.1023/A:1014873923439
M3 - Article
AN - SCOPUS:0036206821
VL - 251
SP - 409
EP - 412
JO - Journal of Radioanalytical and Nuclear Chemistry
JF - Journal of Radioanalytical and Nuclear Chemistry
SN - 0236-5731
IS - 3
ER -