Preparation of Conjugates for Affibody-Based PNA-Mediated Pretargeting

Mohamed Altai, Anzhelika Vorobyeva, Vladimir Tolmachev, Amelie Eriksson Karlström, Kristina Westerlund

Результат исследований: Материалы для книги/типы отчетовГлава

1 Цитирования (Scopus)

Аннотация

Affibody molecules are small engineered scaffold proteins suitable for in vivo tumor targeting. Radionuclide molecular imaging using directly radiolabelled affibody molecules provides excellent imaging. However, affibody molecules have a high renal reabsorption, which complicates their use for radionuclide therapy. The high renal reabsorption is a common problem for the use of engineered scaffold proteins for radionuclide therapy. Affibody-based PNA-mediated pretargeting reduces dramatically the absorbed dose to the kidneys and makes affibody-based radionuclide therapy possible. This methodology might, hopefully, solve the problem of high renal reabsorption for radionuclide therapy mediated by other engineered scaffold proteins.

Язык оригиналаАнглийский
Название основной публикацииMethods in Molecular Biology
ИздательHumana Press Inc.
Страницы283-304
Число страниц22
DOI
СостояниеОпубликовано - 2020
Опубликовано для внешнего пользованияДа

Серия публикаций

НазваниеMethods in Molecular Biology
Том2105
ISSN (печатное издание)1064-3745
ISSN (электронное издание)1940-6029

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Fingerprint Подробные сведения о темах исследования «Preparation of Conjugates for Affibody-Based PNA-Mediated Pretargeting». Вместе они формируют уникальный семантический отпечаток (fingerprint).

Цитировать