Preparation of biocompatible composites based on poly-L-lactide/ hydroxyapatite and investigation of their anti-inflammatory activity

Yelena Shapovalova, Daria Lytkina, Liudmila Rasskazova, Ilya Zhuk, Alexandru Gudima, Anatoly Filimoshkin, Natalya Korotchenko, Irina Kurzina, Julia Kzhyshkowska

    Результат исследований: Материалы для книги/типы отчетовМатериалы для конференции

    5 Цитирования (Scopus)

    Аннотация

    Relevance of the work is due to the need for new materials that are used in medicine as a substitute for natural bone tissue injuries, fractures, etc. The aim of the work is to obtain composites with improved biocompatible properties based on poly-L-lactide (PLA) and hydroxyapatite (HA) and to perform pilot analysis of interaction PLA, HA, composite PLA-HA with primary human monocytes-derived macrophages in vitro. The pilot experiments using human primary monocytes cultivated on the surface of the samples demonstrated that PLA-HA can stimulate release of antiinflammatory cytokines that indicates the presence of potential anti-inflammatory properties of the composites.

    Язык оригиналаАнглийский
    Название основной публикацииMultifunctional Materials
    Подзаголовок основной публикацииDevelopment and Application
    ИздательTrans Tech Publications Ltd
    Страницы475-480
    Число страниц6
    ISBN (печатное издание)9783038357292
    DOI
    СостояниеОпубликовано - 1 янв 2016
    Событие12th International Conference on Prospects of Fundamental Sciences Development, PFSD 2015 - Tomsk, Российская Федерация
    Продолжительность: 21 апр 201524 апр 2015

    Серия публикаций

    НазваниеKey Engineering Materials
    Том683
    ISSN (печатное издание)1013-9826

    Конференция

    Конференция12th International Conference on Prospects of Fundamental Sciences Development, PFSD 2015
    СтранаРоссийская Федерация
    ГородTomsk
    Период21.4.1524.4.15

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    ASJC Scopus subject areas

    • Materials Science(all)
    • Mechanics of Materials
    • Mechanical Engineering

    Цитировать

    Shapovalova, Y., Lytkina, D., Rasskazova, L., Zhuk, I., Gudima, A., Filimoshkin, A., Korotchenko, N., Kurzina, I., & Kzhyshkowska, J. (2016). Preparation of biocompatible composites based on poly-L-lactide/ hydroxyapatite and investigation of their anti-inflammatory activity. В Multifunctional Materials: Development and Application (стр. 475-480). (Key Engineering Materials; Том 683). Trans Tech Publications Ltd. https://doi.org/10.4028/www.scientific.net/KEM.683.475