Preclinical toxicological evaluation of pentamang and mangascan

A. A. Churin, G. V. Karpova, T. I. Fomina, T. V. Vetoshkina, T. Yu Dubskaya, O. L. Voronova, V. D. Filimonov, M. L. Belyanin, V. Yu Usov

Результат исследований: Материалы для журналаСтатьярецензирование

4 Цитирования (Scopus)

Аннотация

We have carried out a preclinical toxicological investigation (acute toxicity evaluation) of Mangascan (0.5 M solution of manganese(II) - EDTA complex) and Pentamang (0.5 M solution of manganese(II) - DTPA complex), a new paramagnetic contrast agents for MRI procedures. In 14 days after single intravenous introduction of Mangascan (10.0 ml/kg) or Pentamang (5.0 ml/kg) to rats, no any toxic influence of the studied agents was detected in the general condition, bone marrow, cardiovascular and central nervous systems, and liver and kidney functions of experimental animals. No pathological changes were observed in the functional activity and morphology of the internal organs and systems. The results showed that both Mangascan and Pentamang belong to the class of low toxicity substances.

Язык оригиналаАнглийский
Страницы (с-по)49-52
Число страниц4
ЖурналEksperimental'naya i Klinicheskaya Farmakologiya
Том71
Номер выпуска4
СостояниеОпубликовано - 2008

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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